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タグ「LET」

Dose-response and relative biological effectiveness of fast neutrons: induction of apoptosis and inhibition of neurogenesis in the hippocampus of adult mice

Author: M. Yang, J.S. Kim, M.S. Song et al.

Reference: Int. J. Radiat. Biol. ― 2010. ― Vol. 86, № 6. ― P. 476–485.

Keywords: linear energy transfer, hippocampal dentate gyrus, mice

Abstract: PURPOSE: Our study compared the effects of high linear energy transfer (LET) fast neutrons on the induction of apoptosis and reduction of neurogenesis in the hippocampus of adult ICR mice with those of low-LET (60)Co gamma-rays, to evaluate the relative biological effectiveness (RBE) of fast neutrons in the adult hippocampal dentate gyrus (DG).

MATERIALS AND METHODS: The mice were exposed to 35 MeV fast neutrons or (60)Co gamma-rays. We evaluated acutely the incidence of apoptosis and expression of Ki-67 (a protein marker for cell proliferation originally defined by the monoclonal antibody Kiel-67) and doublecortin (DCX: an immature progenitor neuron marker) in the hippocampus after a single whole-body irradiation.

RESULTS: The number of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labelling (TUNEL)-positive apoptotic nuclei in the DG increased and both Ki-67- and DCX-positive cells declined in a dose-dependent pattern, with fast neutrons or gamma-rays. In the hippocampus, which showed an apoptosis frequency between 2 and 8 per DG, the RBE of fast neutrons was approximately 1.9. Additionally, the inhibitory effects of fast neutrons on the expression frequencies of Ki-67 (4-8) and DCX (8-32) were approximately 3.2 and 2.5 times, respectively, the effects of gamma-rays at the same dose.

CONCLUSIONS: Increased apoptotic cell death and decreased neurogenesis in the hippocampal DG were seen in a dose-dependent pattern after exposure to fast neutrons and gamma-rays. In addition, the different rate of hippocampal neurogenesis between different radiation qualities may be an index of RBE.

URL: http://www.ncbi.nlm.nih.gov/pubmed/20470197

Concerns With Low-Level Ionizing Radiation * * Based on a Grand Rounds presentation at the Mayo Clinic on Sept. 16, 1992.

 

Title: Concerns With Low-Level Ionizing Radiation * * Based on a Grand Rounds presentation at the Mayo Clinic on Sept. 16, 1992.
Author: YALOW, ROSALYN S.

Reference: Mayo Clinic Proceedings, 69 (5), p.436-440, May 1994
doi: 10.1016/S0025-6196(12)61639-5

Keywords: LET, linear energy transfer, Low-Level Ionizing Radiation

Abstract: …of radiation-induced thyroid nodules is higher than the risk of radiation-induced thyroid cancer. Therefore, as part of the International Chernobyl Project in 1990, data…obtained about the nature of thyroid nodules in the population…

URL: http://www.sciencedirect.com/science/article/pii/S0025619612616395

Concerns With Low-Level Ionizing Radiation * * Based on a Grand Rounds presentation at the Mayo Clinic on Sept. 16, 1992.

Title: Concerns With Low-Level Ionizing Radiation * * Based on a Grand Rounds presentation at the Mayo Clinic on Sept. 16, 1992.
Author: YALOW, ROSALYN S.
Reference: Mayo Clinic Proceedings, 69 (5), p.436-440, May 1994
doi: 10.1016/S0025-6196(12)61639-5
Keywords: LET, linear energy transfer
Abstract: Studies of populations in geographic areas of increased cosmic radiation and high natural background radiation, radiation-exposed workers, patients with medical exposure to radioactivity, and accidental exposure are reviewed.

…of radiation-induced thyroid nodules is higher than the risk of radiation-induced thyroid cancer. Therefore, as part of the International Chernobyl Project in 1990, data…obtained about the nature of thyroid nodules in the population…

URL: http://www.sciencedirect.com/science/article/pii/S0025619612616395

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