タグ「low dose」
Author: H. Korr, H. Thorsten Rohde, J. Benders et al.
Reference: Int. J. Radiat. Biol. — 2001. — Vol. 77, № 5. — P. 567–580.
Keywords: prenatal low-dose X-irradiation, hippocampal pyramidal cells
Abstract: PURPOSE: Apart from subsequent cell death, little is known about long-term effects of a prenatal low-dose X-irradiation (PLDI) on nuclear (n) and mitochondrial (mt) DNA, and whether these effects are connected with reduced neuron numbers in the adult brain.
MATERIALS AND METHODS: Pregnant mice were X-irradiated with 0, 10 or 50cGy at day 13 (E13) of pregnancy. One day after (E14), or postnatally at day 25 (P25) or P180, the brains of the offspring were analysed concerning the extent of nDNA repair, mt biogenesis, and the relative content of nDNA single strand breaks (SSB). Stereology was applied for evaluating neuronal loss.
RESULTS: One day after irradiation no unrepaired SSB were detected. Significant results were mainly obtained for hippocampal pyramidal cells at P180, particularly cell loss following 50 cGy PLDI, increased SSB content and mt biogenesis (0 vs. 10cGy) but decreased mt biogenesis for 10 vs. 50 cGy.
CONCLUSIONS: A hypothesis closely related to that regarding molecular events during aging is presented for explaining this second wave of cell death in adult mice following PLDI as a result of accumulated mtDNA damage caused by PLDI. A possible relation to the neurodegenerative hypothesis of schizophrenia is discussed.
URL: http://www.ncbi.nlm.nih.gov/pubmed/11382335
Author: Loganovsky K.N.
Reference: Florence, Italy, January 17-19, 2013. — pp. 77–85
Author: E. Yin, D.O. Nelson, M.A. Coleman et al.
Reference: Int. J. Radiat. Biol. ― 2003. ― Vol. 79, № 10. ― P. 759–775.
Keywords: gene expression, metabolic function, DNA
Abstract: PURPOSE: To characterize the cellular functions associated with the altered transcript profiles of mouse brain exposed to low-dose in vivo gamma-irradiation.
MATERIALS AND METHODS: Cerebral RNA was isolated at 30 min and 4 h after whole-body irradiation at 0.1 or 2 Gy, hybridized to random oligonucleotide arrays, and evaluated for time and dose-response patterns by multifactorial analyses.
RESULTS: Brain irradiation modulated the expression patterns of 1574 genes, of which 855 showed more than 1.5-fold variation. about 30% of genes showed dose-dependent variations, including genes exclusively affected by 0.1 Gy. About 60% of genes showed time-dependent variation with more genes affected at 30 min than at 4 h. Early changes involved signal transduction, ion regulation and synaptic signalling. Later changes involved metabolic functions including myelin and protein synthesis. Low-dose radiation also modulated the expression of genes involved in stress response, cell-cycle control and DNA synthesis/repair.
CONCLUSIONS: Doses of 0.1 Gy induced changes in gene expression that were qualitatively different from those at 2 Gy. The findings suggest that low-dose irradiation of the brain induces the expression of genes involved in protective and reparative functions, while down-modulating genes involved in neural signalling activity.
URL: http://www.ncbi.nlm.nih.gov/pubmed/20399419
Title: Low doses of ionizing radiation: health effects and assessment of radiation risks for emergency workers of the Chernobyl accident
Author: Ivanov V.K., Tsyb A.F., Ivanov S.I., Souchkevitch G.N. /Editors G.N.Souchkevitch, M.N.Repacholi.
Reference: Geneva: World Health Organization, 2001. – 277 p.
doi:
Keywords: Low doses
Abstract: …..Chapter 6. Trends of cancer incidence among the Chernobyl emergency workers: estimation of radiation risks
6.1. Analytical methods
6.2. Estimation of radiation risks of leukemia and thyroid cancer (cohort studies, 1986-1993)
6.3. Dose response of leukemias (cohort studies, 1986-1996)
6.4. Analysis of incidence of leukemia among emergency workers (case control study, 1986-1993)
6.5. Estimation of radiation risks of solid cancers (cohort studies, 1986-1996)…..
URL: http://www.nrer.ru/monograf.html
Title:
Author: Golivets T.P., Kovalenko B.S.
Reference: Journal” ПАЛЛИАТИВНАЯ МЕДИЦИНА И РЕАБИЛИТАЦИЯ» No.4 2011
ISSN: 2079-4193
Keywords: CANCER, THE BELGOROD REGION, THE CHERNOBYL NUCLEAR POWER PLANT ACCIDENT, LOW, MALIGNANT NEOPLASMS
Abstract:
URL: http://elibrary.ru/item.asp?id=17239200
Title: Increased incidence of malignancies in Sweden after the Chernobyl accident-a promoting effect?
Author: Martin Tondel, Peter Lindgren,1 Peter Hjalmarsson,Lennart Hardell, Bodil Persson4
Reference: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 49:159–168 (2006) [PDF-140K]Mar 2011
Keywords: caesium-137; ionising radiation; nuclear power; low dose; epidemiology; environment; background radiation; cancer; GIS; cohort
Abstract: After the Chernobyl accident in 1986, as much as 5% of the released caesium-137 was deposited in Sweden due to a heavy rainfall 2 days after the event. A study of increased incidence of malignancies was initiated after the accident.
URL: http://www.ippnw.org/pdf/chernobyl-increased-incidence-malignancies-sweden.pdf
