タグ「neoplasms」
Title: View of Pathologist on Medical Consequences of the Chernobyl Accident: Neoplasms
Author: Lushnikov E.F
Reference: Journal” МЕДИЦИНСКАЯ РАДИОЛОГИЯ И РАДИАЦИОННАЯ БЕЗОПАСНОСТЬ“53- 1 : 2008
ISSN: 0025-8334
Keywords: CHERNOBYL ACCIDENT, MEDICAL CONSEQUENCES, NEOPLASMS, THYROID CARCINOMA
Abstract: Purpose: To review medical consequences of the Chernobyl accident taking oncological morbidity and mortality in population as example. Material and methods: Data of the demographic and medical statistics of oncological morbidity and mortality as well as results of studies fulfilled by colleagues of the laboratory of pathological anatomy headed by author of the paper were used. Results: It was established that morbidity and mortality rates of malignant neoplasms that could be/not be related to consequences of the accident were varied in different regions of Russia. Completeness and reliability of the data of oncological statistics were acceptable for the public health organization but insufficient for assessment of medical consequences of the accident for past years and estimation of risks for population morbidity and mortality resulted from malignant tumors that could be induced by ionizing radiation as the statistics does not take into consideration the peculiarities of the onco-nosological forms. There were several reasons (difficulties of diagnostics, death of the majority of patients at home, lack or insufficient pre- or post-mortal morphological diagnosis verification, low quality of medical and statistical documentation) that created obstacles for improvement of the quality of medical information. More reliable data of morbidity and mortality in population exposed to the accidental radiation could be obtained from the special registry based on the information that controlled by morphological verification of diagnosis. Analysis of morbidity and mortality in accordance with the 1CD-10 can not provide any notion about relationship between pathology and various factors of accident as each of onco-nosological form has own etiological, pathogenetical, clinico-anatomical peculiarities and should be specially analyzed.
URL: http://elibrary.ru/item.asp?id=10019507
Title: Fetal cell carcinogenesis of the thyroid: Theory and practice
Author: Takano, Toru
Reference: Seminars in Cancer Biology, 17 (3), p.233-240, Jun 2007
doi: 10.1016/j.semcancer.2006.02.001
Keywords: Neoplasms; Stem cells; Thyroid gland; Gene expression; Fetal cell research
Abstract: …dominant in the fetal thyroid. This fact suggests…estrogen may help the fetal thyroid to increase its volume…hypothesis. First, in the Chernobyl accident, radioactive…the ability to induce thyroid cancer in adults, induced papillary…
URL: http://www.sciencedirect.com/science/article/pii/S1044579X06000228
Title: Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer
Author: Heinz-Ulrich G. Weier, Yuko Ito, Johnson Kwan, Jan Smida , Jingly F. Weier, Ludwig Hieber, Chung-Mei Lu, Lars Lehmann, Mei Wang, Haig J. Kassabian, Hui Zeng, Benjamin O’Brien
Reference: Genes 2011, 2, 397-419; [PDF-768K]Jul 2011
doi: 10.3390/genes2030397
Keywords: Chernobyl; neoplastic disease; papillary thyroid cancer; translocation; molecular cytogenetics; breakpoint delineation; fluorescence in situ hybridization; bacterial artificial chromosomes
Abstract: …tumors and papillary thyroid carcinomas (PTCs…regions. Keywords: Chernobyl neoplastic disease papillary thyroid cancer translocation molecular…studies of post-Chernobyl cases of PTC…radiation-induced childhood thyroid cancer: S96T, as…
URL: http://www.mdpi.com/2073-4425/2/3/397/pdf-vor
Title: How shall we manage the incidentally found thyroid nodule?
Author: Aspinall, Sebastian R. / Ong, Sarah G.S. / Wilson, Michael S.J. / Lennard, Thomas W.J.
Reference: The Surgeon, In Press, Corrected Proof,Jan 2013
doi: 10.1016/j.surge.2012.11.004
Keywords: Thyroid; Thyroid nodule; Thyroid neoplasm; Ultrasonography; Cytology
Abstract: …Table 1 Risk factors for thyroid cancer on history. Risk factor for thyroid cancer Previous head and neck irradiation Exposure to nuclear fallout e.g. from Chernobyl Family history of medullary thyroid carcinoma or multiple endocrine neoplasia…
URL: http://www.sciencedirect.com/science/article/pii/S1479666X12001230
Title: Estimated long term health effects of the Chernobyl accident
Author: Cardis, E. [International Agency for Research on Cancer, Lyon (France)]
Reference: Jul 1996 DOE Scientific and Technical Information
Keywords: 56 BIOLOGY AND MEDICINE, APPLIED STUDIES ;54 ENVIRONMENTAL SCIENCES; CHERNOBYLSK-4 REACTOR; RADIATION ACCIDENTS; NEOPLASMS; PROBABILISTIC ESTIMATION; HUMAN POPULATIONS; BIOLOGICAL RADIATION EFFECTS; THYROID; BELARUS; RUSSIAN FEDERATION; UKRAINE; EPIDEMIOLOGY; CESIUM 137
Abstract: …These increases would be difficult to detect epidemiologically against an expected background number of 41500 and 433000 cases of cancer respectively among the two groups. The exposures for populations due to the Chernobyl accident are different in type and pattern from those of the survivors of the atomic bombing of Japan. Thus predictions derived from studies of these populations are uncertain. The extent of the incidence of thyroid cancer was not envisaged. Since only ten years have lapsed since the accident, continued monitoring of the health of the population is essential to assess the public health impact.
URL: http://www.osti.gov/bridge/product.biblio.jsp?query_id=2&page=0&osti_id=381695
Title: Post-Chernobyl thyroid carcinoma in children
Author: Leenhardt, Laurence / Aurengo, André
Reference: Best Practice & Research Clinical Endocrinology & Metabolism, 14 (4), p.667-677, Dec 2000
doi: 10.1053/beem.2000.0109
Keywords: Chernobyl; accidents, radiation; children, thyroid carcinoma; thyroid neoplasms/*genetics; carcinoma, papillary/*genetics; molecular sequence data; mutation/*genetics; gene rearrangement; Ukraine; Belarus
Abstract: The dramatic increase in childhood thyroid carcinoma observed in Belarus and Ukraine as early as 4 years after the Chernobyl nuclear accident, is well recognized as being a consequence of exposure to radioactive iodine fallout. Uncertainties persist concerning the contamination and the dosimetric data. Thyroid nodule, cervical lymph nodes or systematic ultrasound thyroid screening in exposed children led to the diagnosis….
URL: http://www.sciencedirect.com/science/article/pii/S1521690X0090109X
Title: Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer
Author: Heinz-Ulrich G. Weier, Yuko Ito, Johnson Kwan, Jan Smida, Jingly F. Weier, Ludwig Hieber, Chun-Mei Lu, Lars Lehmann , Mei Wang , Haig J. Kassabian, Hui Zeng, Benjamin O’Brien
Reference: [PDF-770K]Jul 2011
Keywords: Chernobyl; neoplastic disease; papillary thyroid cancer; translocation; molecular cytogenetics; breakpoint delineation; fluorescence in situ hybridization; bacterial artificial chromosomes
Abstract: …tumors and papillary thyroid carcinomas (PTCs…regions. Keywords: Chernobyl neoplastic disease papillary thyroid cancer translocation molecular…studies of post-Chernobyl cases of PTC…radiation-induced childhood thyroid cancer: S96T, as…
URL: http://www.mdpi.com/2073-4425/2/3/397/pdf
Title: Thyroid cancer in children: the Royal Marsden Hospital experience
Author: Landau, D. / Vini, L. / A’Hern, R. / Harmer, C.
Reference: European Journal of Cancer, 36 (2), p.214-220, Jan 2000
doi: 10.1016/S0959-8049(99)00281-6
Keywords: Thyroid; Neoplasm; Childhood
Abstract: …neck dissection; TB, thyroid bed; CR, complete response; PR, partial…Introduction Carcinoma of the thyroid is rare in children…irradiation following the Chernobyl nuclear power station…however, childhood thyroid cancer seems to behave in a…
URL: http://www.sciencedirect.com/science/article/pii/S0959804999002816
Title: Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
Author: Cotterill, S.J. / Pearce, M.S. / Parker, L.
Reference: European Journal of Cancer, 37 (8), p.1020-1026, May 2001
doi: 10.1016/S0959-8049(00)00449-4
Keywords: Thyroid neoplasms; Childhood cancer; Young adults; Iodine radioisotopes; Nuclear accidents
Abstract: Population-based data on thyroid carcinomas was obtained from the Northern Region Young Person’s Malignant Disease Registry to analyse the incidence of thyroid cancers in young people (<25 years) in the North of England for the period 1968 and 1997 and to assess if changes in incidence were consistent with the spatial and temporal distribution of the fallout from the Chernobyl nuclear accident. We compared incidence rates for differentiated (papillary or follicular) thyroid carcinomas 1968–1986 with those for 1987–1997. …These temporal and spatial changes in incidence are consistent with a causal association with the Chernobyl accident although a greater effect in the younger rather than the older age group would have been anticipated. However, factors including improvements in ascertainment and earlier detection of tumours may also have contributed to the increasing incidence. …
URL: http://www.sciencedirect.com/science/article/pii/S0959804900004494
Title: No increase in thyroid cancer among children and adolescents in Finland due to Chernobyl accident
Author: But, Anna / Kurttio, Päivi / Heinävaara, Sirpa / Auvinen, Anssi,
Reference: European Journal of Cancer, 42 (8), p.1167-1171, May 2006
doi: 10.1016/j.ejca.2006.03.006
Keywords: Radiation effects; Thyroid neoplasms; Incidence; Chernobyl; Finland
Abstract: The aim of the study was to assess whether radioactive fallout from the Chernobyl accident in 1986 influenced thyroid cancer incidence among children and adolescents in Finland. The population was divided into two: those with thyroid doses less than 0.6 mSv and above 0.6 mSv. Cumulative incidence of thyroid cancer was identified from the Finnish Cancer Registry from a population aged 0–20 years in 1986 with a total of 1,356,801 persons. No clear difference in underlying thyroid cancer incidences rates were found during the pre-Chernobyl period (1970–1985) (rate ratio RR 0.95, 95% confidence interval CI 0.81–1.10). During the post-Chernobyl period (1991–2003), thyroid cancer incidence was lower in the more exposed population than in the less exposed population (RR 0.76, 95% CI 0.59–0.98). Our results did not indicate any increase in thyroid cancer incidence related to exposure to radiation from the Chernobyl accident.
URL: http://www.sciencedirect.com/science/article/pii/S0959804906002358
