VERIFICATION OF ORGANIC BRAIN DAMAGE IN REMOTE PERIOD OF ACUTE RADIATION SICKNESS
Author: Loganovsky K N, Kovalenko A N, Yuryev K L, Bomko Maria A, Antipchuk Ekaterina Yu, Denisyuk N V, Zdorenko Leonid L, Rossokha A P, Chorny A I, Dubrovina G V
Reference: Український медичний часопис (Ukrainian Medical Magazine), 2003
Keywords: organic brain damage, clinical neuropsychiatric, neuropsychological, neurophysiological, and neuroimaging surveys
Abstract: The problem of verification of organic brain damage in remote period of acute radiation sickness (ARS) is of a great significance due to the radiovulnerability of the brain is still at issue. The goal of the study was to verify the organic brain damage in remote period of ARS by clinical neuropsychiatric, neuropsychological, neurophysiological, and neuroimaging surveys of cerebral structural and functional abnormalities. The endophormous (apathetic) postradiation brain organic syndrome (encephalopathy) is compressed by microfocal neurological signs, personality disorders, negative psychopathological symptoms, depression and cognitive deficit. The structural and functional brain damage involving the frontal lobes and the left temporal lobe together with their cortico-subcortical connections and deep brain structures were revealed by neuropsychological investigation. There were dominating EEG-patterns as follows: the disorganized with predominance of a- and big spectral power of slow activity EEG-pattern and low-voltage polymorphous EEG-pattern with predominance of d- and b-power. Atherosclerotic changes, hypertensive vessel tonus, interhemispheric asymmetry of blood supply (decreased in the left hemisphere), as well as high frequency of stenos were the causes of cerebral haemodynamics disorders. Brain structural pathology revealed by magnetic-resonance imaging, predominantly, brain atrophy, enlargement of ventricula, and lacunar brain abnormalities, supported the cerebro-organic nature of the disorders. Thus, the organic brain damage in remote period of ARS has been verified by clinical neuropsychiatric.
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