WHETHER CHRONIC FATIGUE SYNDROME AND METABOLIC SYNDROME X IN CHERNOBYL ACCIDENT SURVIVORS ARE MEMBRANE PATHOLOGY?
Author: A.N. Kovalenko, K.N. Loganovsky
Reference: Український медичний часопис (Ukrainian Medical Magazine), 2001
Keywords: Chronic Fatigue Syndrome, Metabolic Syndrome X, liquidators, the Chernobyl accident, channelopathy, membranopathy, effects of ionising radiation
Abstract: Frequency, the trends of development, and outcomes of Chronic Fatigue Syndrome (CFS) and Metabolic Syndrome X (MSX) in clean-up workers of the consequences of the Chernobyl accident (liquidators) were studied as well as an attempt was made for consideration of a community of these syndromes pathogenesis in the light of the current data in radiobiology and radiation medicine. During 1990–2001 there were examined randomly selected 367 liquidators of 1986–1987. It was established that CFS frequency significantly (p<0,001) decreased (from 65,5% in 1990–1995 to 10,5% in 1996–2001) and MSX frequency significantly (p<0,001) increased (from 15 to 48,2%). CFS and MSX are considered to be the stages of another neuropsychiatric and physical pathology development, and CFS can transform towards MSX. A significant role of channelopathy (including radiation-induced) in the mechanisms of the development of CFS and MSX is discussed. Mitochondrial genome disorders together with changes of transmembrane ionic transport could be the basis of CFS and MSX. Radiation-induced damage of mitochondrial DNA in post-mitotic tissues with low proliferation activity may be a one of the basis of the effects of low doses concerning an increase of non-cancer morbidity and mortality in the Chernobyl accident survivors. Radiation effects launch at the sub-membrane, membrane and post-membrane levels could further integrate in the systemic and intrasystemic levels that, finally, together with genetic predisposition and exposure to other promoter factors lead towards the development of non-specific radiation syndromes, in particular, CFS and MSX.(Full text in Russian on web)
URL: http://www.umj.com.ua/wp-content/uploads/archive/26/pdf/820_rus.pdf?upload
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