カテゴリー「genetics / gene mutation」
Title: Equal induction and persistence of chromosome aberrations involving chromosomes 1, 4 and 10 in thyroid cancer patients treated with radioactive iodine
Author: Puerto, S / Marcos, R / Ramı́rez, M.J / Galofré, P / Creus, A / Surrallés, J
Reference: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 469 (1), p.147-158, Aug 2000
doi: 10.1016/S1383-5718(00)00064-4
Keywords: Chromosome aberrations; Painting; Persistence; Radioactive iodine; Thyroid cancer
Abstract: …developing thyroid cancer [22,23…incidence of thyroid cancer has been reported…result of the Chernobyl nuclear power…radiation after the Chernobyl disaster and…bioaccumulation in the thyroid gland, it…in thyroid cancer. The uptake…
URL: http://www.sciencedirect.com/science/article/pii/S1383571800000644
Title: Mechanisms and pathogenesis of thyroid cancer in animals and man
Author: Williams, E.D.
Reference: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 333 (1-2), p.123-129, Dec 1995
doi: 10.1016/0027-5107(95)00138-7
Keywords: Thyroid cancer; mechanisms and pathogenesis
Abstract: The transformation of the normal fully differentiated thyroid follicular cell to the rapidly growing undifferentiated anaplastic thyroid carcinoma cell involves a number of stages which have been defined morphologically and are now being related to various growth pathways and to molecular biological defects. The two main factors involved in this transformation are growth stimulation and mutagenesis…. The recent large increase in papillary carcinoma of the thyroid in children exposed to fallout from the Chernobyl nuclear accident underlines the importance of understanding the pathobiology of thyroid neoplasia.
URL: http://www.sciencedirect.com/science/article/pii/0027510795001387
Title: Evaluation of the reticulocyte micronucleus assay in patients treated with radioiodine for thyroid cancer
Author: Grawé, Jan / Biko, Johannes / Lorenz, Reinhard / Reiners, Christoph / Stopper, Helga / Vershenya, Stanislav / Vukicevic, Vladimir / Hempel, Klaus
Reference: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 583 (1), p.12-25, May 2005
doi: 10.1016/j.mrgentox.2005.01.010
Keywords: Radioiodine; Radiation therapy; Micronuclei; Immature; Reticulocytes; Biological dosimetry; Flow cytometry
Abstract: …patients during the radioiodine treatment for thyroid cancer. Most patients were children or young adults, who have developed thyroid cancer years after the reactor accident of Chernobyl. Some details about the treatment and…
URL: http://www.sciencedirect.com/science/article/pii/S1383571805000574
Title: Micronucleus frequency in Gomel (Belarus) children affected and not affected by thyroid cancer
Author: Zotti-Martelli, Laura / Migliore, Lucia / Panasiuk, Galina / Barale, Roberto
Reference: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 440 (1), p.35-43, Mar 1999
doi: 10.1016/S1383-5718(99)00012-1
Keywords: Human lymphocyte micronucleus assay; Thyroid cancer; Chernobyl accident; Ionizing radiation
Abstract: Cytogenetic monitoring was carried out on a group of children from Gomel (Belarus), one of the areas most severely affected by radioactive contamination following the accident at the Chernobyl nuclear power plant, in 1986. We performed the micronucleus test (MN) in binucleated lymphocytes of 42 children (mean age: 11±2.34 years), 16 of whom were affected by thyroid gland tumor. Thirty healthy children living in Pisa (mean age: 14.96±2.17 years) were enrolled in the study as controls….
URL: http://www.sciencedirect.com/science/article/pii/S1383571899000121
Title: Dose response for T-cell receptor (TCR) mutants in patients repeatedly treated with 131 I for thyroid cancer
Author: Vershenya, Stanislav / Biko, Johannes / Drozd, Valentina / Lorenz, Reinhard / Reiners, Christoph / Hempel, Klaus
Reference: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 548 (1-2), p.27-33, Apr 2004
doi: 10.1016/j.mrfmmm.2003.12.015
Keywords: T-cell receptor; Mutation; Radiation; Thyroid cancer; Chernobyl
Abstract: The T-cell receptor mutant frequency (TCR-Mf) was measured in 53 young adults, who were treated with radioiodine for thyroid cancer. Patients came from the southern part of Belarus. This region had suffered the most from the Chernobyl Disaster. TCR-Mf was determined by flow cytometry before and after 1 to maximal 10 treatments. Before treatment, TCR-Mf of patients was 2.0×10−4. This Mf value is in the same range as that of young healthy students. After radioiodine therapy (RIT), TCR-Mf increases within about half a year to a maximum…
URL: http://www.sciencedirect.com/science/article/pii/S0027510704000223
