Can different thyroid tumor types be distinguished by polymerase chain reaction-based K- ras mutation detection?

Title: Can different thyroid tumor types be distinguished by polymerase chain reaction-based K- ras mutation detection?
Author: Apple, Sophia K. / Alzona, Maria C. / Jahromi, Soraya A. / Grody, Wayne W.

Reference: Molecular Diagnosis, 3 (3), p.143-148, Sep 1998

doi: 10.1016/S1084-8592(98)80032-5

Keywords: follicular adenoma; follicular carcinoma; papillary carcinoma; oncogenes

Abstract: Thyroid tumors have mutations of the ras oncogenes, although the prognostic and diagnostic significance of this remains unclear. Usually, thyroid follicular adenoma, follicular carcinoma, and papillary carcinoma are easy to differentiate histologically. Occasionally, follicular carcinoma may be difficult to separate from the follicular variant of papillary carcinoma, and a molecular test to help differentiate the two would be critical, as their behavior and clinical management differ. In earlier reports, K-ras mutations have been suggested as such a marker.

…normal and proliferative thyroid tissues. Am J Pathol…carcinomas arising from thyroid epithe- lial follicular cells. Gene Chromosomes Cancer 1996;16:1-14 22…benign and malignant thyroid tumors from children…to radiation after the Chernobyl nuclear accident. Oncogene…

URL: http://www.sciencedirect.com/science/article/pii/S1084859298800325

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