Author: D. Bazyka, I. Ilyenko, K. Loganovsky et al.
Reference: Abstracts of 17th ECDO Euroconference on apoptosis «Destruction, degradation and death cell death control in cancer and neurodegeneration», September 23–26, 2009, Institut Pasteur, Paris, France. — P. 63.
Author: S. Sadetzki, A. Chetrit, L. Freedman et al.
Reference: Radiat. Res. — 2005. — Vol. 163, № 4. — P. 424–432.
Keywords: tinea capitis treatment, aftermath
Abstract: Ionizing radiation is an established risk factor for brain tumors, yet quantitative information on the long-term risk of different types of brain tumors is sparse. Our aims were to assess the risk of radiation-induced malignant brain tumors and benign meningiomas after childhood exposure and to investigate the role of potential modifiers of that risk. The study population included 10,834 individuals who were treated for tinea capitis with X rays in the 1950s and two matched nonirradiated groups, comprising population and sibling comparison groups. The mean estimated radiation dose to the brain was 1.5 Gy. Survival analysis using Poisson regression was performed to estimate the excess relative and absolute risks (ERR, EAR) for brain tumors. After a median follow-up of 40 years, an ERR/Gy of 4.63 and 1.98 (95% CI = 2.43-9.12 and 0.73-4.69) and an EAR/Gy per 10(4) PY of 0.48 and 0.31 (95% CI = 0.28-0.73 and 0.12-0.53) were observed for benign meningiomas and malignant brain tumors, respectively. The risk of both types of tumors was positively associated with dose. The estimated ERR/Gy for malignant brain tumors decreased with increasing age at irradiation from 3.56 to 0.47 (P = 0.037), while no trend with age was seen for benign meningiomas. The ERR for both types of tumor remains elevated at 30-plus years after exposure.
Author: I. Yaar, E. Ron, B. Modan et al.
Reference: J. Neurol. Neurosurg. Psychiatry. — 1982. — Vol. 45, № 2. — P. 166–169.
Keywords: EEG, visual analyses, tinea capitis treatment
Abstract: EEG tracings were compared in 44 young adults who received scalp x-radiation treatment for tinea capitis during childhood and 59 non-irradiated control subjects. The irradiated subjects were exposed, over 20 years previously, to a mean dose of 130 rads to the brain. Visual analysis of the EEG revealed an insignificant excess of abnormalities among the irradiated subjects compared to the controls. Power spectral density function analysis showed increased power values among the irradiated subjects, particularly in the beta wave frequencies. This finding provides further evidence for suspecting that x-irradiation during brain maturation may cause long-lasting damage to the brain tissue. (full text in English available on web)
Author: Loganovsky KN, Zdanevich NA.
Reference: CNS Spectr. 2013, 18 (2): 95–102.
Keywords: PTSD, cerebrovascular pathology, hippocampus, depression
Abstract: BACKGROUND: Whether posttraumatic stress disorder (PTSD) following radiation emergency has psychopathological, neurocognitive, and neurophysiological peculiarities is at issue.
OBJECTIVE: The goal was to explore the features and cerebral basis of “radiation” PTSD in the survivors of the Chernobyl accident. Subjects and Methods The cross-sectional study included 241 people, 219 of whom have been diagnosed with PTSD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) criteria, among them 115 clean-up workers of the Chernobyl accident (34 with acute radiation sickness), 76 evacuees from the Chernobyl exclusion zone, 28 veterans of the war in Afghanistan, and 22 healthy unexposed individuals. Psychometric examinations, neurocognitive assessments, computerized electroencephalography, and cerebral vascular Doppler were used.
RESULTS: “Radiation” PTSD includes “flashforward” phenomena and anticipating stress (projection of fear and danger to the future); somatoform disorders (depression, trait and state anxiety); and neurocognitive deficit (impaired memory and attention, auditory-verbal memory and learning, proactive and retroactive interference, cerebellar and stem symptoms, intellectual changes). The intima-media component, thickness of common carotid arteries, and common and left internal carotid arteries stenosis rates are increased in the liquidators. Changes of bioelectrical brain activity as a decrease of beta- and theta-power, together with an increase of alpha-power, were found in the Chernobyl accident survivors with PTSD.
CONCLUSIONS: PTSD following radiation emergency is characterized by comorbidity of psychopathology, neurocognitive deficit, and cerebrovascular pathology with increased risk of cerebral atherosclerosis and stroke. The cerebral basis of this PTSD is proposed to be an abnormal communication between the pyramidal cells of the neocortex and the hippocampus, and deep brain structures. It is recommended that a system of emergency and long-term psychological and psychiatric care be organized for the survivors in Fukushima Daichi, Japan.
Author: Loganovsky KN, Loganovskaja TK, Nechayev SY, Antipchuk YY, Bomko MA.
Reference: J. Neuropsychiatry Clin Neurosci. 2008, 20 (3): 274–291.
Keywords:EEG patterns, children, mothers, WISC
Abstract: One hundred children, exposed prenatally to radiation after the Chernobyl nuclear power plant accident, and 50 non-exposed classmates were examined between the ages of 11 and 13 years old using neuropsychiatric tests, WISC, EEG, and visual evoked potentials. Individual prenatal radiation doses were reconstructed for all examined children. The exposed children were found to have more neuropsychiatric disorders, left-brain neurological signs, lower full-scale and verbal IQ, IQ discrepancies with verbal decrement, disorganized EEG patterns, an excess of lateralized-to-left frontotemporal region delta and beta power with depression of theta and alpha power, and interhemispheric inversion visual information processing. Mothers’ mental health, stress, and prenatal irradiation contributed to these effects, along with several confounding factors. (full text in English available on web.)
URL: http://neuro.psychiatryonline.org/article.aspx?articleID=103418
Author: Loganovsky K.N., Zdorenko L.L.
Reference: Clinical Neuropsychiatry. — 2012. — Vol. 9, № 5. — P. 187-194
Keywords: IQ, cognitive impairment, ARS
Abstract: Full text in English available on web.
URL: http://www.clinicalneuropsychiatry.org/pdf/Loganovsky_sito.pdf
Author: Loganovsky K.N., Yuryev K.L.
Reference: J. Neuropsychiatry Clin. Neurosci. — 2004. — Vol. 16, № 1. — P. 70–82.
Keywords: qEEG, neurophysiological markers, left fronto-temporal dominant frequency reduction
Abstract: Cross-sectional quantitative electroencephalogram (qEEG) study (1996—2001) among Chernobyl accident survivors, who had confirmed acute radiation sickness and were irradiated in dose of 1—5 Gy, revealed the neurophysiological markers of ionizing radiation. Neuropsychological markers were: left fronto-temporal dominant frequency reduction; absolute δ-power lateralization to the left (dominant) hemisphere; relative δ-power increase in the fronto-temporal areas; absolute θ-power decrease in the left temporal region; absolute and relative α-power diffusive decrease, which may reflect cortico-limbic dysfunction lateralized to the left, dominant hemisphere, with the fronto-temporal cortical and hippocampal damage. Quantitative electroencephalogram proposed for differentiation of radiation and nonradiation brain damages and as a new biological dosymetry method. High radiosensitivity of the brain, neocortex, and dominant hemisphere higher radiosensitivity are discussed.
URL: http://neuro.psychiatryonline.org/article.aspx?articleID=101854
Author: Loganovsky K.N., Yuryev K.L.
Reference: J. Neuropsychiatry Clin. Neurosci. — 2001. — Vol. 13, № 4. — P. 441–458
Keywords: EEG, cortical-limbic overactivation, organic brain damage
Abstract: Prospective conventional EEG study was carried out 3-5 and 10-13 years after the Chernobyl accident (1986) in patients who had acute radiation sickness and in emergency workers in 1986 (“liquidators”). Control groups comprised healthy volunteers; veterans of the Afghanistan war with posttraumatic stress disorder; veterans with mild traumatic brain injury; and patients with dyscirculatory encephalopathy. In 3-5 years after irradiation, there were irritated EEG changes with paroxysmal activity shifted to the left frontotemporal region (cortical-limbic overactivation) that were transformed 10-13 years after irradiation toward a low-voltage EEG pattern with excess of fast (beta) and slow (delta) activity together with depression of alpha and theta activity (organic brain damage with inhibition of the cortical-limbic system). Quantitative EEG is likely to be very informative for investigation of dose-effect relationships.
URL: http://neuro.psychiatryonline.org/article.aspx?articleid=101516
Author: Loganovsky K.N., Loganovskaja T.K.
Reference: Schizophr. Bull. — 2000. — Vol. 26, № 4. — P. 751–773.
Keywords: schizophrenia, psychophysiological examination, left frontotemporal limbic and schizophreniform syndromes
Abstract: We studied schizophrenia spectrum disorders in Chernobyl accident survivors by analyzing Chernobyl exclusion zone (EZ) archives (1986-1997) and by conducting a psychophysiological examination of 100 patients with acute radiation sickness (ARS) and 100 workers of the Chernobyl EZ who had worked as “liquidators-volunteers” for 5 or more years since 1986-1987. Beginning in 1990, there has been a significant increase in the incidence of schizophrenia in EZ personnel in comparison to the general population (5.4 per 10,000 in the EZ versus 1.1 per 10,000 in the Ukraine in 1990). Those irradiated by moderate to high doses (more than 0.30 Sv or 30 rem), including ARS patients, had significantly more left frontotemporal limbic and schizophreniform syndromes. We hypothesized that ionizing radiation may be an environmental trigger that can actualize a predisposition to schizophrenia or indeed cause schizophrenia-like disorders. The development of schizophrenia spectrum disorders in overirradiated Chernobyl survivors may be due to radiation-induced left frontotemporal limbic dysfunction, which may be the neurophysiological basis of schizophrenia-like symptoms. Persons exposed to 0.30 Sv or more are at higher risk of schizophrenia spectrum disorders. An integration of international efforts to discuss and organize collaborative studies in this field is of great importance for both clinical medicine and neuroscience. (full text available on web)
URL: http://schizophreniabulletin.oxfordjournals.org/content/26/4/751.long
Author: Loganovsky K.N.
Reference: Journal of Chronic Fatigue Syndrome. — 2000. — Vol. 7, № 3. — P. 3–16.
Keywords: CFS, MMPI, qEEG, SSEP
Abstract: The aim of this study was to determine whether the Chronic Fatigue Syndrome (CFS) definition could be applicable to the assessment of the medical aftermath of radioecological disasters and to investigate a possible psychophysiological basis of fatigue in Chernobyl accident survivors.
One hundred randomly selected clean-up workers of the Chernobyl accident who presented with complaints of fatigue were examined neuropsychiatrically using MMPI profiles, Quantitative Electroencephalography (QEEG) and Somatosensory evoked potentials (SSEP). Twenty-six percent of them met the CFS diagnostic criteria. Their absorbed radiation doses were less than 0.3 Sv, an exposure level that is not expected to produce a clear deterministic radiation effect. Clinical symptomatology included persistent fatigue, odd skin sensations, bizarre feelings in bones, muscles and joints, irritability, headache, vertigo, pain in the chest area, emotional lability, irritability, lack of concentration and memory, cognitive deterioration,
depression signs and sleep disorders.
UTL: http://www.ncf-net.org/radiation/Vegetative_dystonia_CFS.pdf