タグ「BRAF」
Title: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
Author: Nikiforova, Marina N / Ciampi, Raffaele / Salvatore, Giuliana / Santoro, Massimo / Gandhi, Manoj / Knauf, Jeffrey A / Thomas, Gerry A / (…) / Nikiforov, Yuri E
Reference: Cancer Letters, 209 (1), p.1-6, Jun 2004
doi: 10.1016/j.canlet.2003.12.004
Keywords: Thyroid cancer; BRAF mutation; RET/PTC Rearrangement; Radiation exposure
Abstract: Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
URL:http://www.sciencedirect.com/science/article/pii/S0304383503008334
Title: Reply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
Author: Lima, Jorge / Trovisco, Vítor / Soares, Paula / Máximo, Valdemar / Magalhães, João / Salvatore, Giuliana / Santoro, Massimo / (…) / Sobrinho-Simões, Manuel
Reference: Cancer Letters, 230 (1), p.149-150, Dec 2005
doi: 10.1016/j.canlet.2004.10.053
Keywords: BRAF mutation; Thyroid cancer; Chernobyl; Ionizing radiation
Abstract: Our findings both support and extend those of Nikiforova et al. [M.N. Nikiforova, R. Ciampi, G. Salvatore, M. Santoro, M. Gandhi, J.A. Knauf, et al., Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas, Cancer Lett. 209 (2004) 1–6]: BRAF mutations are rare in childhood PTC, both in an irradiation setting and in sporadic tumors.
URL: http://www.sciencedirect.com/science/article/pii/S0304383505000029
Title: Molecular pathology of thyroid cancer: diagnostic and clinical implications
Author: Fagin, James A. / Mitsiades, Nicholas
Reference: Best Practice & Research Clinical Endocrinology & Metabolism, 22 (6), p.955-969, Dec 2008
doi: 10.1016/j.beem.2008.09.017
Keywords: thyroid cancer; pathogenesis; oncogene; RET; BRAF; RAS; molecular diagnostics; PTEN; PI3 kinase
Abstract: …receptor (RET/PTC) in thyroid cells that are constitutively…a very early event in thyroid cancer development. Thus…11 or RET/PTC3 12 in thyroid cells. In addition…characteristics. In post-Chernobyl pediatric cancers RET…
URL: http://www.sciencedirect.com/science/article/pii/S1521690X08001127
Title: Vía de señalización dependiente de la proteincinasa de activación mitogénica en el carcinoma papilar de tiroides. De las bases moleculares a la práctica clínica
Author: Zafon, Carles / Obiols, Gabriel
Reference: Endocrinología y Nutrición, 56 (4), p.176-186, Apr 2009
doi: 10.1016/S1575-0922(09)70982-9
Keywords: Papillary thyroid carcinoma; MAPK; RET/PTC; BRAF
Abstract: …tiroides INTRODUCCIÓN El cáncer de tiroides es la…caracterizar correctamente el cáncer de tiroides debe residir…la central nuclear de Chernobyl 26 . Además, estudios…en casos de CPT tras Chernobyl es baja y no…variedades histológicas del cáncer de dicha glándula…
URL: http://www.sciencedirect.com/science/article/pii/S1575092209709829
