(日本語) チェルノブイリ事故後慢性持続性低線量電離放射線に曝露したウクライナの患者の腎明細胞癌における微小血管密度は高い
Title: Microvessel density is high in clear-cell renal cell carcinomas of Ukrainian patients exposed to chronic persistent low-dose ionizing radiation after the Chernobyl accident
Author: A. M. Romanenko, A. Ruiz-Saurí, L. Morell-Quadreny, G. Valencia, A. F. Vozianov, A. Llombart-Bosch
Reference: Virchows Archiv , June 2012, Volume 460, Issue 6, pp 611-619
DOI: 10.1007/s00428-012-1243-x
Keywords : Conventional renal cell carcinoma, Ionizing radiation, Angiogenesis, Microvessel density, CD31antibody
Abstract: During the 25-year period subsequent to the Chernobyl accident, the morbidity of malignant renal tumors in Ukraine has increased from 4.7 to 10.7 per 100,000 of the total population. Recent studies of our group have shown that increases in morbidity, aggressiveness, and proliferative activity of renal cell carcinomas (RCCs), especially clear-cell renal cell carcinoma (CCRCC), in Ukrainian patients continuously inhabiting the radio-contaminated areas could be explained by specific molecular changes influenced by the so-called “chronic persistent low-dose ionizing radiation” (CPLDIR) exposure. This study aimed to examine the role of angiogenesis in CCRCC carcinogenesis associated with CPLDIR in patients living more than 20 years in cesium 137 (137Cs) contaminated areas after the Chernobyl accident in Ukraine. Paraffin-embedded specimens of 106 CCRCs were studied: Control cases were 18 tumors from Spanish patients (group 1), 25 tumors from Ukrainian patients from so-called clean areas without known radio-contamination (group 2), and 63 tumors from Ukrainian patients from radio-contaminated areas (group 3).
URL：http://link.springer.com/article/10.1007/s00428-012-1243-x