タグ「Iodine-131」
Title: Micronucleus formation in lymphocytes of children from the vicinity of Chernobyl after 131I therapy
Author: W.-U. Müller, S. Dietl, K. Wuttke, C. Reiners, J. Biko, E. Demidchik, C. Streffer
Reference: Radiation and Environmental Biophysics , May 2004, Volume 43, Issue 1, pp 7-13
doi: 10.1007/s00411-004-0233-z
Keywords : Lymphocytes, children, Iodine-131, thyroid tumours
Abstract: After the Chernobyl accident a statistically significant increase in the number of children with thyroid tumours was observed. In this study 166 children with and 75 without thyroid tumours were analysed for micronucleus formation in peripheral blood lymphocytes using the cytochalasin B approach. The following factors did not significantly affect micronucleus formation: gender, age at the time of the first 131I treatment, tumour stage, tumour type, or metastases; a statistically significant increase in the number of micronuclei, however, was observed for the residents of Gomel compared to other locations, such as Brest, Grodno, and Minsk. The children with tumours received 131I treatment after surgical resection of the tumours. This gave us the opportunity to systematically follow the effect of 131I on micronucleus formation. A marked increase was observed 5 days after the 131I treatment followed by a decrease within a 4–7 months interval up to the next application, but the pre-treatment levels were not achieved. Up to 10 therapy cycles were followed each including an analysis of micronucleus formation before and 5 days after 131I application. The response of the children was characterised by clear individual differences and the increase/decrease pattern of micronucleus frequencies induced by iodine-131 was correlated with a decrease/increase pattern in the number of lymphocytes.
ＵＲＬ: http://link.springer.com/article/10.1007/s00411-004-0233-z
Title: Retrospective analysis of I-129 for the estimation of I-131 deposition following the Fukushima accident
Author: Yasuyuki Muramatsu, Hirouyuki Matsuzaki, Takeshi Ohno, Chiaki Toyama
Reference: Abstracts of Annual Meeting of the Geochemical Society of Japan
Keywords: iodine-129, iodine-131, Fukushima nuclear accident, deposition, contamination map
ＵＲＬ：https://www.jstage.jst.go.jp/article/geochemproc/60/0/60_189/_article
Title:Average radiation doses to residents of the South Ukraine caused by the accident at the Chernobyl NPP
Author: Grigorieva L.I.
Reference: Journal: Radiation and Risk (Bulletin of the National Radiation and Epidemiological Registry), Year: 2011 Volume: 20 Issue: 3
Keywords:reconstruction, inhalation and oral intake of 131І, radioisotopes of cesium (137Cs; 134Cs), noble radioactive gases (85mKr; 133mXe), Effective dose, 06Ru, 103Ru, 141Ce, 144Ce, 95mNb, 132Te, 140Ln
Abstract: Results of retrospective reconstruction of average individual radiation doses got by residents of the South Ukraine due to exposure to radioactive fallouts from the Chernobyl NPP are given in the article. In the work radiometry, spectrometry and dosimetry data collected in the territory of Nikolev, Odessa, Kirovograd oblasts and Autonomous Republic of Crimea were used. The study was carried out by the Nikolaev Research Laboratory Larani in 1986 and later.
URL:http://cyberleninka.ru/article/n/srednie-dozy-oblucheniya-zhiteley-yuga-ukrainy-obuslovlennye-avariey-na-chaes
Title: The dependence of incidence rates of non-cancer thyroid diseases in the post-natal period at the Kaluga oblast children from term gestation, on which has taken place them in utero irradiation owing to technogenic iodine-131 incorporation
Author: Gorobets V.F
Reference: Radiation and Risk (Bulletin of the National Radiation and Epidemiological Registry) Year: 2011 Volume: 20 Issue: 1
Keywords: children, incidence of non-cancer thyroid diseases, irradiation in utero, technogenic iodine-131, cohort study
Abstract: The results of investigation of non-cancer thyroid diseases incidence rates, relative risks and etio-logic fractions by cohort study at 420 children from southwest region of the Kaluga oblast for the 12-year’s period after irradiation in utero on various terms of gestation at the expense of the technogenic iodine-131 incorporation are presented. Also 150 not exposed children as the control group was observed. It was established that incidence rates of thyroid diseases in the children irradiated in utero was at 2.6 times more than in the control group. The incidence of thyroid diseases among the children irradiated in utero was depended on the period of gestation at which irradiation was occurred. The highest level of the thyroid diseases incidence rate was in two subgroups of irradiated children: in the first subgroup every member was irradiated at the expense of iodine-131 from 4-th to 12-th week of gestation, in the second subgroup – from 16-th to 22-th week of gestation. It is known from radiobiological investigations that at these periods of gestation thyroid of foetus intensively accumulates radioactive iodine.
URL:http://cyberleninka.ru/article/n/zavisimost-urovney-zabolevaemosti-neonkologicheskimi-zabolevaniyami-schitovidnoy-zhelezy-v-postnatalnom-periode-u-detey-iz-kaluzhskoy
Title: Comparative analysis of thyroid diseases incidence in prepubertal children of Kaluga oblast, exposed to iodine-131 in utero and resided in areas with different level of radioactive contamination after the Chernobyl accident
Author: Gorobets V.F
Reference: Radiation and Risk (Bulletin of the National Radiation and Epidemiological Registry) Year: 2012 Volume: 21 Issue: 4
Keywords: children, in utero exposure to radiation, pollution of territories by iodine-131 and caesium-137, iodine supplementation, thyroid diseases incidence.
Abstract: Incidence of non-cancer thyroid diseases among prepubertal children exposed to radiation from Chernobyl in utero and resided in Zhizdra, Ulyanovo and Khvastovichi rayons of Kaluga oblast with different level of radioactive contamination was studied. It was shown that the rate of thyroid diseases incidence depended on natural iodine insufficiency in the areas of residence and radioiodine dose. The relative contribution of each of these factors can be estimated by difference between the incidence rate in exposed and unexposed children of the same age and the same area of residence.
URL:http://cyberleninka.ru/article/n/sravnitelnyy-analiz-zabolevaemosti-tireopatiyami-v-dopubertatnom-vozraste-detey-iz-kaluzhskoy-oblasti-obluchyonnyh-vnutriutrobno-za
Title: Distribution of oceanic 137Cs from the Fukushima Dai-ichi Nuclear Power Plant simulated numerically by a regional ocean model
Author: Daisuke Tsumune, Takaki Tsubono, Michio Aoyama, Katsumi Hirose
Reference: Journal of Environmental Radioactivity, Volume 111, September 2012, Pages 100–108
DOI: http://dx.doi.org/10.1016/j.jenvrad.2011.10.007
Keywords: Fukushima reactor accident; Regional ocean model; Release rate; 137Cs; 131I/137Cs activity ratio
Abstract: Radioactive materials were released to the environment from the Fukushima Dai-ichi Nuclear Power Plant as a result of the reactor accident after the Tohoku earthquake and tsunami of 11 March 2011. The measured 137Cs concentration in a seawater sample near the Fukushima Dai-ichi Nuclear Power Plant site reached 68 kBq L−1 (6.8 × 104 Bq L−1) on 6 April. The two major likely pathways from the accident site to the ocean existed: direct release of high radioactive liquid wastes to the ocean and the deposition of airborne radioactivity to the ocean surface. By analysis of the 131I/137Cs activity ratio, we determined that direct release from the site contributed more to the measured 137Cs concentration than atmospheric deposition did.
URL: http://www.sciencedirect.com/science/article/pii/S0265931X11002463
Title: Preliminary evaluation of the impact of the Chernobyl radiological contamination on the frequency of central nervous system malformations in 18 regions of Europe
Reference: Paediatric and Perinatal Epidemiology, Volume 2, Issue 3, pages 253–264, July 1988
DOI: 10.1111/j.1365-3016.1988.tb00216.x
Keywords: human breast milk; Iodine-131; radioiodine
Abstract: The teratological impact of radiological contamination from the Chernobyl accident was evaluated in relation to central nervous system and eye defects in 18 regional registries in nine countries of Western Europe. Six classes of anomaly were analysed: neural tube defects, arhinencephaly, microcephaly and brain reduction, hydrocephaly, anophthalmos and microphthalmos, and congenital cataract. Conceptions up to 31 August 1986 were grouped into two exposure cohorts. In cohort A the sensitive period of fetal development to radiation fell wholly or partly between 1 May and 30 June 1986. Cohort B included all cases exposed during their sensitive period on or after 1 May 1986. Observed frequencies of the six classes of anomaly in the exposed cohorts were compared with expected frequencies calculated from baseline rates for the period 1980–1985. The only significant increase was neural tube defects in Odense, Denmark (four cases observed in cohort A where 0.9 were expected). The results of the study do not show a general increase in the frequency of malformations in the countries of Western Europe. The evidence presented indicates that, in the regions studied, termination of pregnancies or invasive prenatal diagnostic examinations were not justified for women exposed during pregnancy.
URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3016.1988.tb00216.x/abstract
Title: Effect of the Fukushima nuclear power plant accident on radioiodine (131I) content in human breast milk
Author: Nobuya Unno, Hisanori Minakami, Takahiko Kubo, Keiya Fujimori, Isamu Ishiwata, Hiroshi Terada, Shigeru Saito, Ichiro Yamaguchi, Naoki Kunugita, Akihito Nakai, Yasunori Yoshimura
Reference: Journal of Obstetrics and Gynecology Research, Volume 38, Issue 5, pages 772–779, May 2012
Keywords: human breast milk; Iodine-131; nuclear power plant accident; radioiodine
Abstract: Environmental pollution with radioiodine (iodine-131, 131I) occurred after an accident at the Fukushima nuclear power plant (FNP) on March 11, 2011, in Japan. Whether environmental pollution with 131I can contaminate human breast milk has not been documented. The 131I content was determined in 126 breast milk samples from 119 volunteer lactating women residing within 250 km of the FNP, between April 24 and May 31, 2011. The degree of environmental pollution was determined based on the data released by the Japanese government.
URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1447-0756.2011.01810.x/abstract
Title: Iodine-131 Late Effects in Case of Childhood Exposure
Author: Mushkacheva G. S., Rabinovich E.I., Privalov V.A., Povolotskaya S.V., Ryzhova E.F., Shorokhova V.B., Turdakova V.A., Sokolova S. N.
Reference: Journal «МЕДИЦИНСКАЯ РАДИОЛОГИЯ И РАДИАЦИОННАЯ БЕЗОПАСНОСТЬ» vol.: 51 No. 2 2006
ISSN: 0025-8334
Keywords: RADIATION EXPOSURE, IODINE-131, THYROID GLAND, LATE EFFECTS, THYROID DISEASES, NODULAR GOITER
Abstract: Purpose: The assessment of thyroid pathology incidence in later life after 1-131 exposure in childhood in population residing in the area affected by the operation of nuclear industry enterprise. Material and methods: 1,062 residents of Ozyorsk, the city near Mayak PA, the first nuclear industry enterprise in Russian Federation, were subjected to thyroid screening. The main studied group (707) has included individuals born in 1950-1953 in Ozyorsk or the ones who moved in Ozyorsk within the first two years since birth. The reference group (355) included Ozyorsk residents born elsewhere and moved in the city after 1967 when releases of iodine-131 were minimized. The developed screening procedure included the obvious clinical, ultrasound and biochemical examinations. Individuals with any thyroid abnormalities revealed were sent to additional examinations and to an endocrinologist who has diagnosed patients and prescribed therapy. Results: Total frequency of thyroid pathology was 28 % (difference between main and reference groups was insignificant). The structure of diseases was dominated by nodular goiter (65 %), followed by autoimmune thyroiditis (23 %), and diffuse goiter (9 %), benign and malignant tumors – 3 %. Analysis of separate thyroid diseases revealed statistically significant increase of nodular goiter incidence in main group, especially in females (sex- and heredity-adjusted relative risk (RR) of exposure was 2.1, confidence interval (CI) of 1.4-3.2). Large nodules (10 mm diameter and more) were found more frequently among members of the exposed group than these in the non-exposed group (RR = 2.67, CI = 1.2-5.94). Non-nodular forms of thyroid diseases in main group were more often complicated by hormonal disorders (hypothyroidism), and had a tendency toward greater expressed signs of autoimmune invasion (increased count of antibodies to the thyroidal per-oxidase). Conclusion: Exposure to I-131 in early childhood in cohort of Ozyorsk residents increases in two time the relative risk of nodular goiter development in followed life. Risk increase of large solitary nodules development in thyroid of I-131 exposed individuals was revealed. Non-nodular thyroid diseases occurred on persons in the main group were more often complicated with functional disorders.
URL: http://elibrary.ru/item.asp?id=9186386
Author: E.I. Masharova
Reference: Chelyabinsk 2003 WAC Russia 14.00.05
Keywords: iodine 131, early childhood, remote effects
Abstract: Purpose of the work is to study and evaluate the structural changes of the thyroid gland, in remote period after accident, in persons exposed to iodine-131 in early childhood.
URL: http://medical-diss.com/medicina/strukturnye-izmeneniya-schitovidnoy-zhelezy-u-lits-podvergshihsya-oblucheniyu-radioaktivnym-yodom-v-detskom-vozraste
