タグ「RET/PTC」
Title: RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics.
Author: Leeman-Neill RJ, Brenner AV, Little MP, Bogdanova TI, Hatch M, Zurnadzy LY, Mabuchi K, Tronko MD, Nikiforov YE.
Reference: Cancer. 2013 Feb 21.
doi: 10.1002/cncr.27893.
Keywords: RET/PTC, chromosomal rearrangements, PAX8/PPARγ, iodine-131
Abstract: These results provide the first demonstration of PAX8/PPARγ rearrangements in post-Chernobyl tumors and show different associations for point mutations and chromosomal rearrangements with (131) I dose and other factors. These data support the relationship between chromosomal rearrangements, but not point mutations, and (131) I exposure and point to a possible role of iodine deficiency in generation of RET/PTC rearrangements in these patients. Cancer 2013;. © 2013 American Cancer Society.
URL: http://www.ncbi.nlm.nih.gov/pubmed/23436219
Title: Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas
Author: Unger, K., Zitzelsberger, H., Salvatore, G.*, Santoro, M.*, Bogdanova, T.*, Braselmann, H., Kastner, P.,Zurnadzhy, L.*, Tronko, N.*, Hutzler, P., Thomas, G.:. J.
Reference: Clin. Endocr. Metab. 89, 4272-4279 (2004)
Keywords:
Abstract: The nuclear disaster that occurred in Chernobyl in 1986 offered the unique opportunity to study the molecular genetics of one human tumor type, papillary carcinoma of the thyroid gland, associated with a specific etiology. We have analyzed RET rearrangements in post-Chernobyl papillary thyroid carcinomas (n = 29), follicular thyroid adenomas (n = 2), and follicular thyroid carcinoma (n = 1) by interphase fluorescence in situ hybridization (FISH) analysis on paraffin-embedded tissue sections. Paraffin sections were microdissected before use to ensure that only tumor was present. Cell nuclei were scored for the presence of a split FISH signal (separated red and green signal) in addition to an overlapping signal. Only cells with either two overlapping signals or one split and one overlapping signal were counted to ensure that only complete cell nuclei had been scored. In total, 23 of 32 cases (72%) showed RET rearrangements diagnosed by FISH interphase analysis. In all cases, the tumors were composed of a mixture of cells with and without ret rearrangement on FISH. In some cases, this distribution was clearly nonrandom because clustering of rearranged cells was detected within the same tumor nodule. Accordingly, only 31% of the cases positive for rearrangement on FISH also scored positive using RT-PCR. These findings suggest that because RET/PTC rearrangements are not present in a majority of tumor cells, either a fraction of post-Chernobyl papillary thyroid tumors are of multiclonal origin, or ret rearrangement is a later, subclonal event.
URL: http://www.ncbi.nlm.nih.gov/pubmed/15356021
Title: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
Author: Nikiforova, Marina N / Ciampi, Raffaele / Salvatore, Giuliana / Santoro, Massimo / Gandhi, Manoj / Knauf, Jeffrey A / Thomas, Gerry A / (…) / Nikiforov, Yuri E
Reference: Cancer Letters, 209 (1), p.1-6, Jun 2004
doi: 10.1016/j.canlet.2003.12.004
Keywords: Thyroid cancer; BRAF mutation; RET/PTC Rearrangement; Radiation exposure
Abstract: Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
URL:http://www.sciencedirect.com/science/article/pii/S0304383503008334
Title: Mechanisms of chromosomal rearrangements in solid tumors: The model of papillary thyroid carcinoma
Author: Gandhi, Manoj / Evdokimova, Viktoria / Nikiforov, Yuri E.
Reference: Molecular and Cellular Endocrinology, 321 (1), p.36-43, May 2010
doi: 10.1016/j.mce.2009.09.013
Keywords: Thyroid cancer; RET/PTC; Nuclear architecture; DNA repair
Abstract: …risk factor for thyroid cancer, especially for papillary…increased incidence of thyroid cancer has been documented…radiation after the Chernobyl nuclear disaster in…2006 ). Studied of thyroid cancer in various populations…
URL:http://www.sciencedirect.com/science/article/pii/S0303720709004961
Title: Vía de señalización dependiente de la proteincinasa de activación mitogénica en el carcinoma papilar de tiroides. De las bases moleculares a la práctica clínica
Author: Zafon, Carles / Obiols, Gabriel
Reference: Endocrinología y Nutrición, 56 (4), p.176-186, Apr 2009
doi: 10.1016/S1575-0922(09)70982-9
Keywords: Papillary thyroid carcinoma; MAPK; RET/PTC; BRAF
Abstract: …tiroides INTRODUCCIÓN El cáncer de tiroides es la…caracterizar correctamente el cáncer de tiroides debe residir…la central nuclear de Chernobyl 26 . Además, estudios…en casos de CPT tras Chernobyl es baja y no…variedades histológicas del cáncer de dicha glándula…
URL: http://www.sciencedirect.com/science/article/pii/S1575092209709829
