Atomic neuropsychiatry: 25 years after the Chernobyl catastrophe
Author: K.N. Loganovsky
Keywords: atomic neuropsychiatry
Abstract: full text in Russian available on web, on the pages 26~41 of the net journal.
カテゴリー「neurology」
Effect of ionizing radiation on the nervous system
Author: A.V. Lebedinsky, Z.N. Nakhilnitskaya
Reference: Атомиздать (Atom publishing), 1960
Keywords: dose-dependent effect, nervous system, X-ray exposure, EEG
WHETHER CHRONIC FATIGUE SYNDROME AND METABOLIC SYNDROME X IN CHERNOBYL ACCIDENT SURVIVORS ARE MEMBRANE PATHOLOGY?
Author: A.N. Kovalenko, K.N. Loganovsky
Reference: Український медичний часопис (Ukrainian Medical Magazine), 2001
Keywords: Chronic Fatigue Syndrome, Metabolic Syndrome X, liquidators, the Chernobyl accident, channelopathy, membranopathy, effects of ionising radiation
Abstract: Frequency, the trends of development, and outcomes of Chronic Fatigue Syndrome (CFS) and Metabolic Syndrome X (MSX) in clean-up workers of the consequences of the Chernobyl accident (liquidators) were studied as well as an attempt was made for consideration of a community of these syndromes pathogenesis in the light of the current data in radiobiology and radiation medicine. During 1990–2001 there were examined randomly selected 367 liquidators of 1986–1987. It was established that CFS frequency significantly (p<0,001) decreased (from 65,5% in 1990–1995 to 10,5% in 1996–2001) and MSX frequency significantly (p<0,001) increased (from 15 to 48,2%). CFS and MSX are considered to be the stages of another neuropsychiatric and physical pathology development, and CFS can transform towards MSX. A significant role of channelopathy (including radiation-induced) in the mechanisms of the development of CFS and MSX is discussed. Mitochondrial genome disorders together with changes of transmembrane ionic transport could be the basis of CFS and MSX. Radiation-induced damage of mitochondrial DNA in post-mitotic tissues with low proliferation activity may be a one of the basis of the effects of low doses concerning an increase of non-cancer morbidity and mortality in the Chernobyl accident survivors. Radiation effects launch at the sub-membrane, membrane and post-membrane levels could further integrate in the systemic and intrasystemic levels that, finally, together with genetic predisposition and exposure to other promoter factors lead towards the development of non-specific radiation syndromes, in particular, CFS and MSX.(Full text in Russian on web)
URL: http://www.umj.com.ua/wp-content/uploads/archive/26/pdf/820_rus.pdf?upload
Clinico-dosimetric analysis of peculiarities of intellectual development and emotional and behavioral disorders in children with oncologic pathologies on the thyroid gland
Author: S.A. Igumnov
Reference: Український медичний часопис (Ukrainian Medical Magazine), 1998
Keywords: thyroid cancer, intellectual development, emotional and behavioral disorders in children
MENTAL WORKING CAPACITY IN LIQUIDATORS WITH ORGANIC MENTAL DISORDERS IN THE REMOTE PERIOD AFTER THE CHERNOBYL ACCIDENT
Author: L.L. Zdorenko, K.N. Loganovsky
Reference: Український медичний часопис (Ukrainian Medical Magazine), 2002
Keywords: mental working capacity, mental fitness, clean-up workers, Chernobyl accident, acute radiation sickness, organic mental disorders
Abstract: Mental working capacity in the remote period after the Chernobyl accident in liquidators with organic mental disorders (n=106), including patients who had been diagnosed with acute radiation sickness (n=48), was assessed with clinical, psychometric and psychophysiological methods. Mental working capacity is significantly reduced due to motivation disturbances as a result of personality, emotional-volitional and cognitive disorders against the background of organic brain damage of combined genesis. The level of mental working capacity in the remote period of acute radiation sickness is determined with its severity degree (36%), social-economic factors (27%), psychopathology (15%), somatoneurological pathology (13%) and age (9%). Social-economic factors are the main causes defining the reduction of mental working capacity in the examined liquidators (60%). It is necessary to create the state system of social-psychological rehabilitation for optimisation of mental working capacity in persons exposed as a result of the Chernobyl accident.
URL: http://www.umj.com.ua/wp-content/uploads/archive/30/pdf/741_rus.pdf?upload
Changes of EEG coherence in different stages of the formation of the psychoorganic syndrome
Author: T.S. Mel’nikova, V.N. Krasnov, M.M. Yurkin et al.
Reference: Журн. невропатол. и психиатр. им. С.С. Корсакова. (journal of neuropathology and psychiatry named after S.S. Korsakov), 2010
Keywords: liquidators of Chernobyl Nuclear Power Plant accident, psychoorganic syndrome, EEG coherence analysis
Abstarct: The group of liquidators of Chernobyl Nuclear Power Plant accident (n=170) with nonpsychotic mental disorders of exogenicorganic origin was studied. Patients were stratified into five groups on the basis of dominating symptoms in different stages of disorders: group 1 included patients with the prevalence of asthenic symptoms (n=104); group 2 — with the prevalence of autonomous disorders (n=37); group 3 — with the marked neurotic-like symptom complex (n=10); group 4 — with depressive symptoms (n=10); group 5 — with disturbances of cognitive function. The control group included 150 healthy people. Recording and mapping of coherence (COH) of the brain electrical activity was conducted using the apparatus-software complex for topographic mapping of brain electrical activity NEURO-CM (Russia) with the bandwidth from 0 to 40 Hz and the time constant of 0,3 sec. The EEG record was carried out monopolar from symmetrical cortical zones (10—20% scheme). Changes of COH were characterized by staging in patients compared to the controls. In the initial stage of disease, the integrative links were decreased in the temporal cortical zones of the left hemisphere. The reduction of functional activity in temporal-central cortical zones was found that might be the consequence of mesodiencephalic dysfunction. In the later stages, temporal zones of the right hemisphere were mostly affected. The parallel reinforcement of functional activity of occipital zones, in particular, the increase of “long links” with frontal areas, was noted in the overall formation of the psychoorganic syndrome. This phenomenon may be considered as a compensatory mechanism when the phylogenetically older cortical zones, which are more resistant to pathological changes, become leaders in the realization of integrative brain activity during the development of a pathological state.
(full text in Russian available on web)
Chronic cerebrovascular pathology in the chernobyl accident consequences liquidators, in remote period after radiation exposure
Author: N.V. Denisyuk
Reference: Український медичний часопис (Ukrainian Medical Magazine), 2006
Keywords: ionizing radiation, Chernobyl accident, ultrasonic Dopplerography, cerebrovascular pathology
Abstract: Clinical-angioneurological peculiarities of chronic cerebrovascular pathology in remote period after radiation exposure to doses ranged from 0.025 to 3.5 Sv were determined on the basis of comprehensive clinical and neurophysiological investigations, as well as qualitative and quantitative estimation of the ultrasonic Dopplerography parameters in 100 men exposed to ionizing radiation as a result of the Chernobyl accident (liquidators; main group), 135 patients with cerebrovascular pathology (comparison group) and 63 healthy men (control group). A target artery (left internal carotid artery/ICA) and the dopplerographic marker of the radiation brain injury in dose range 0.3–3.5 Sv (reduction of the systolic circulation in the left ACI) were revealed. Disturbances of the cerebral hemodynamics in remote period after radiation exposure are etiologically heterogenous; along with general risk factors (age, alcohol abuse, tobacco smoking, somatic pathology) a role of radiation factor was determined at doses exceeded 0.3 Sv. A dose–effect relationship was revealed towards the reduction of the systolic circulation in the left ICA in liquidators irradiated by 0.3–3.5 Sv and without bad habits and liver pathology.
Declarational patent of Ukraine for the efficient model No.46847. Method of diagnosis for postradiational cognitive disorder
Author: K.N. Loganovsky, K.Yu. Antipchuk, G.Yu. Kreinis et al.
Reference: 2010
For detailed information on the article contact the National Scientific Center for Radiation Medicine of Ukraine. The center’s home page is: http://www.national.rcrm.net.ua/index.php/en/
Reaction of the nervous system to harmful ionizing radiation
Author: A.K. Guskova, I.N. Shakirova
Reference: Журн. невропатол. и психиатр. им. С.С. Корсакова. (journal of neuropathology and psychiatry named after S.S. Korsakov), 1989
URL: http://www.kgmu.kcn.ru:8888/cgi-bin/irbis64r_01/cgiirbis_64.exe
Radiation sickness in Man
Author: A.K. Guskova, G.D. Baisogolov (English version available)
Reference: U. S. Atomic Energy Commission. AEC-tr-7401. Biology and medicine
USAEC translation series AEC-tr-7401 (published in Russia in 1971)
Abstract: This book from the 1970’s is still regarded valid and well known among experts all over the world. The author was once the chief doctor of the Moscow Hospital No.6.
URL:http://books.google.co.jp/books/about/Radiation_Sickness_in_Man.html?id=lHobHAAACAAJ&redir_esc=y