カテゴリー「neurology」
Author: Loganovsky K.N., Yuryev K.L.
Reference: J. Neuropsychiatry Clin. Neurosci. — 2004. — Vol. 16, № 1. — P. 70–82.
Keywords: qEEG, neurophysiological markers, left fronto-temporal dominant frequency reduction
Abstract: Cross-sectional quantitative electroencephalogram (qEEG) study (1996—2001) among Chernobyl accident survivors, who had confirmed acute radiation sickness and were irradiated in dose of 1—5 Gy, revealed the neurophysiological markers of ionizing radiation. Neuropsychological markers were: left fronto-temporal dominant frequency reduction; absolute δ-power lateralization to the left (dominant) hemisphere; relative δ-power increase in the fronto-temporal areas; absolute θ-power decrease in the left temporal region; absolute and relative α-power diffusive decrease, which may reflect cortico-limbic dysfunction lateralized to the left, dominant hemisphere, with the fronto-temporal cortical and hippocampal damage. Quantitative electroencephalogram proposed for differentiation of radiation and nonradiation brain damages and as a new biological dosymetry method. High radiosensitivity of the brain, neocortex, and dominant hemisphere higher radiosensitivity are discussed.
URL: http://neuro.psychiatryonline.org/article.aspx?articleID=101854
Author: Loganovsky K.N., Yuryev K.L.
Reference: J. Neuropsychiatry Clin. Neurosci. — 2001. — Vol. 13, № 4. — P. 441–458
Keywords: EEG, cortical-limbic overactivation, organic brain damage
Abstract: Prospective conventional EEG study was carried out 3-5 and 10-13 years after the Chernobyl accident (1986) in patients who had acute radiation sickness and in emergency workers in 1986 (“liquidators”). Control groups comprised healthy volunteers; veterans of the Afghanistan war with posttraumatic stress disorder; veterans with mild traumatic brain injury; and patients with dyscirculatory encephalopathy. In 3-5 years after irradiation, there were irritated EEG changes with paroxysmal activity shifted to the left frontotemporal region (cortical-limbic overactivation) that were transformed 10-13 years after irradiation toward a low-voltage EEG pattern with excess of fast (beta) and slow (delta) activity together with depression of alpha and theta activity (organic brain damage with inhibition of the cortical-limbic system). Quantitative EEG is likely to be very informative for investigation of dose-effect relationships.
URL: http://neuro.psychiatryonline.org/article.aspx?articleid=101516
Author: Loganovsky K.N., Loganovskaja T.K.
Reference: Schizophr. Bull. — 2000. — Vol. 26, № 4. — P. 751–773.
Keywords: schizophrenia, psychophysiological examination, left frontotemporal limbic and schizophreniform syndromes
Abstract: We studied schizophrenia spectrum disorders in Chernobyl accident survivors by analyzing Chernobyl exclusion zone (EZ) archives (1986-1997) and by conducting a psychophysiological examination of 100 patients with acute radiation sickness (ARS) and 100 workers of the Chernobyl EZ who had worked as “liquidators-volunteers” for 5 or more years since 1986-1987. Beginning in 1990, there has been a significant increase in the incidence of schizophrenia in EZ personnel in comparison to the general population (5.4 per 10,000 in the EZ versus 1.1 per 10,000 in the Ukraine in 1990). Those irradiated by moderate to high doses (more than 0.30 Sv or 30 rem), including ARS patients, had significantly more left frontotemporal limbic and schizophreniform syndromes. We hypothesized that ionizing radiation may be an environmental trigger that can actualize a predisposition to schizophrenia or indeed cause schizophrenia-like disorders. The development of schizophrenia spectrum disorders in overirradiated Chernobyl survivors may be due to radiation-induced left frontotemporal limbic dysfunction, which may be the neurophysiological basis of schizophrenia-like symptoms. Persons exposed to 0.30 Sv or more are at higher risk of schizophrenia spectrum disorders. An integration of international efforts to discuss and organize collaborative studies in this field is of great importance for both clinical medicine and neuroscience. (full text available on web)
URL: http://schizophreniabulletin.oxfordjournals.org/content/26/4/751.long
Author: Loganovsky K.N.
Reference: Journal of Chronic Fatigue Syndrome. — 2000. — Vol. 7, № 3. — P. 3–16.
Keywords: CFS, MMPI, qEEG, SSEP
Abstract: The aim of this study was to determine whether the Chronic Fatigue Syndrome (CFS) definition could be applicable to the assessment of the medical aftermath of radioecological disasters and to investigate a possible psychophysiological basis of fatigue in Chernobyl accident survivors.
One hundred randomly selected clean-up workers of the Chernobyl accident who presented with complaints of fatigue were examined neuropsychiatrically using MMPI profiles, Quantitative Electroencephalography (QEEG) and Somatosensory evoked potentials (SSEP). Twenty-six percent of them met the CFS diagnostic criteria. Their absorbed radiation doses were less than 0.3 Sv, an exposure level that is not expected to produce a clear deterministic radiation effect. Clinical symptomatology included persistent fatigue, odd skin sensations, bizarre feelings in bones, muscles and joints, irritability, headache, vertigo, pain in the chest area, emotional lability, irritability, lack of concentration and memory, cognitive deterioration,
depression signs and sleep disorders.
UTL: http://www.ncf-net.org/radiation/Vegetative_dystonia_CFS.pdf
Author: Loganovsky K.N.
Reference: Fiziol Cheloveka. — 2003. — Vol. 29, № 1. — P. 122–130.
Keywords: Chernobyl, Afghanistan, PTSD, Somatosensory evoked potentials
Abstract: Participants of the Chernobyl clean-up (n = 145) teams exposed to radiation doses from 0.05 to 3.5 Gy who had for the first time complained of pathologic somatosensory sensations (ostealgic syndrome), 20 healthy subjects, and 50 veterans of the war in Afghanistan with posttraumatic stress disorder (PTSD) were examined by a neuropsychiatrist and presented with the MMPI test. Somatosensory evoked potentials (SSEPs) were recorded. Paresthesia and cenesthopathy were characteristic of the participants of the Chernobyl clean-up. Sensation disorders of the cerebral type, kinesthetic illusions, cenesthopathic hypochondriac disorders, and paroxysmal psychosensory states predominated in this group of subjects. They differed significantly from the veterans with PTSD in markedly increased scores on MMPI scales (hypochondriasis, schizophrenia, pure hypochondriasis, pure schizophrenia, emotional exclusion, and perception oddity), which closely correlated with clinical somatosensory symptoms. In clean-up workers, somatosensory disorders were significantly associated with hypochondriac and schizophrenic-like symptoms. The latencies (LPs) of main SSEP components—N20, P25, N140, P300, and N400—were increased and their amplitudes decreased in subjects exposed to radiation. Their SSEPs had significant topographical deviations in the left temporoparietal area: the contralateral LPs were increased, whereas the contralateral amplitudes of the thalamocortical N20 component and the cortical P25 component were decreased as compared to normal values. Somatosensory disorders and hypochondriac and schizophrenic symptoms were significantly correlated with changes in the SSEPs. The decrease in the N20 amplitude and increase in the P25 latency in the left temporoparietal area were dose-dependent. The results suggest cerebral rather than peripheral origin of ostealgic syndrome and other somatosensory disorders in the participants of the Chernobyl clean-up. These disorders are associated with radiation-induced dysfunction of the corticolimbic structures of the left—dominant—hemisphere. It is suggested that somatosensory disorders in patients exposed to low doses of radiation can be considered as manifestations of chronic fatigue syndrome /fibromyalgia, whereas schizoform organic brain lesions manifest themselves after exposure to a radiation dose of 0.3–0.5 Gy.
URL: http://link.springer.com/article/10.1023%2FA%3A1022069022557#
Author: Loganovsky K.N.
Reference: Kiev, KIM, 2011, pp. 158–164
Author: Loganovsky K.N.
Reference: Florence, Italy, January 17-19, 2013. — pp. 77–85
Author: Loganovsky K.N.
Reference: Clinical Neuropsychiatry — 2012. — Vol. 9, № 5. — P. 203-204
Author: Loganovsky K., Perchuk I., Nechayev S.
Reference: International Journal of Psychophysiology. — 2010. — Vol. 77, № 3. — P. 0204.
URL: http://www.deepdyve.com/lp/elsevier/brain-mapping-of-quantitative-eeg-before-and-after-exposure-to-low-FsZXyIfF08
Author: Loganovsky K., Bomko M.
Reference: Abstracts of the 8th International LOWRAD Conference «The effects of low doses and very low doses of ionizing radiation on human health and biotopes», 28– 30 September 2009, Rio de Janeiro, Brazil. — Rio de Janeiro, 2009. — P. 116
