カテゴリー「thyroid cancer」
Title: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
Author: Nikiforova, Marina N / Ciampi, Raffaele / Salvatore, Giuliana / Santoro, Massimo / Gandhi, Manoj / Knauf, Jeffrey A / Thomas, Gerry A / (…) / Nikiforov, Yuri E
Reference: Cancer Letters, 209 (1), p.1-6, Jun 2004
doi: 10.1016/j.canlet.2003.12.004
Keywords: Thyroid cancer; BRAF mutation; RET/PTC Rearrangement; Radiation exposure
Abstract: Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
URL:http://www.sciencedirect.com/science/article/pii/S0304383503008334
Title: Irradiation and second cancers. The thyroid as a case in point
Author: Schlumberger, Martin / Cailleux, Anne-Françoise / Suarez, Horacio G / de Vathaire, Florent
Reference: Comptes Rendus de l’Académie des Sciences – Series III – Sciences de la Vie, 322 (2-3), p.205-213, Feb 1999
doi: 10.1016/S0764-4469(99)80045-6
Keywords: irradiation; thyroid tumours; Chernobyl; RET rearrangements
Abstract: …Radioiodine 131 (1311) used for medical purposes has almost no tumourigenic effect on the adult thyroid gland. The consequences of the Chernobyl accident have clearly shown that the risk of thyroid cancer after exposure to 1311 in childhood is important, and that such exposure should be prevented by potassium iodine prophylaxis. RET/PTC rearrangements are found in 60–80 % of papillary carcinomas and in 45 % of adenomas occurring after radiation exposure. They are found in 5–15 % of papillary carcinoma and in no follicular adenomas that occurred in the absence of radiation exposure.
URL:http://www.sciencedirect.com/science/article/pii/S0764446999800456
Title: Radiation Exposures Due to the Chernobyl Accident
Author: Balonov, M. / Bouville, A.
Reference: Encyclopedia of Environmental Health, Jan 2011
ISBN:9780444522726
Keywords: Background radiation; Cesium-137; Chernobyl accident; Effective dose; Environmental consequences; Environmental transfer; Exposure pathways; External dose; Health consequences; Internal dose; Iodine-131; Radionuclide; Thyroid dose
Abstract: …exposure such as the Chernobyl accident, living…Pathways Related to the Chernobyl Accident…environment, such as the Chernobyl accident, is required…accident was an elevated thyroid cancer incidence in children…
URL:http://www.sciencedirect.com/science/article/pii/B9780444522726000866
Title: The World Health Organization and Sasakawa Memorial Health Foundation joint project: medical relief for children affected by the Chernobyl accident through the development and implementation of health telematics
Author: Repacholi, Michael N. / Takamura, Noboru / Souchkevitch, Guennadi N.
Reference: International Congress Series, 1234, p.135-140, May 2002
doi: 10.1016/S0531-5131(01)00604-5
Keywords: Chernobyl; Telemedicine; Health telematics; Thyroid cancer
Abstract: The World Health Organization (WHO) and Sasakawa Memorial Health Foundation (SMFH), in cooperation with the Ministry of Health of the Republic of Belarus (the Ministry), have established and promoted a project entitled “Medical Relief for Children Affected by the Chernobyl Accident through the Development and Implementation of Health Telematics” to improve early diagnosis of thyroid diseases and follow-up of patients who have developed thyroid cancer due to exposure to radioactive fallout. The article reviews the development and current status of the project.
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006045
Title: Chernobyl-induced radiophobia and the incidence of tuberculosis
Author: Takamura, Noboru / Kryshenko, Nikolay / Masyakin, Vladimir / Tamashiro, Hidehiko / Yamashita, Shunichi
Reference: The Lancet, 356 (9225), p.257, Jul 2000
doi: 10.1016/S0140-6736(05)74513-X
Abstract: …to this phenomenon. 3 After the Chernobyl nuclear accident, a significant…increase in the incidence of childhood thyroid diseases was found, particularly in Gomel region of Belarus, where thyroid cancer incidence is 100 times higher than…
URL: http://www.sciencedirect.com/science/article/pii/S014067360574513X
Title: Thyroid gland and radiation (Ukrainian-American Thyroid Project)
Author: Tronko, Mykola D. / Bobylyova, Olga O. / Bogdanova, Tetyana I. / Epshtein, Ovsiy V. / Likhtaryov, Illya A. / Markov, Valentyn V. / Oliynyk, Valery A. / (…) / Voillequé, Paul
Reference: International Congress Series, 1258, p.91-104, Nov 2003
doi: 10.1016/S0531-5131(03)01216-0
Keywords: Chernobyl; Radioiodine; Thyroid gland; Cancer
Abstract: For the period 1998–2002, in the framework of the Ukraine–USA Thyroid Project, medical screening examinations have been conducted to subjects who were aged 0 to 18 years at the time of the Chernobyl accident. These were residents of eight districts, from Kyiv, Chernihiv, and Zhytomyr regions of the Ukraine, having been most affected following the Chernobyl accident, and having received within several weeks after the accident direct measurements of thyroid doses of gamma radiation. For the period 1998–2000, 13227 cohort subjects have undergone screening, and in 2001–2002, a repeat screening was performed. As a result of screening, 64 cases of thyroid carcinoma have been identified, including 43 cases after the first screening and 21 cases after the second screening….
URL:http://www.sciencedirect.com/science/article/pii/S0531513103012160
Title: Radiation-induced thyroid changes: A retrospective and a prospective view
Author: Massimino, Maura / Gandola, Lorenza / Mattavelli, Franco / Pizzi, Natalia / Seregni, Ettore / Pallotti, Federica / Spreafico, Filippo / (…) / Collini, Paola
Reference: European Journal of Cancer, 45 (14), p.2546-2551, Sep 2009
doi: 10.1016/j.ejca.2009.06.009
Keywords: Childhood radiotherapy; Second tumours; Iatrogenic hypothyroidism; Thyroid nodules; Thyroid late-effects
Abstract: …dose of radiation to the thyroid in patients who subsequently…in dosage and cases of cancer is maintained 26 ; higher…the onset of secondary cancer was a median 10 years…documented after the Chernobyl incident. 28 As other…also true of primary thyroid tumours after puberty…
URL: http://www.sciencedirect.com/science/article/pii/S0959804909004389
Title: Immunological Effects of the Chernobyl Accident
Author: Bazyka, D
Reference: Encyclopedia of Environmental Health, Jan 2011
ISBN:9780444522726
Keywords: 12-HETE; Acute radiation syndrome; Chernobyl; Immunity; Lymphocyte; Radiation; Stem cells; T-cell receptor
Abstract: …1 ). The first cancer case was diagnosed…NK) cells and cancer induction after radiation exposure in Chernobyl victims, but…incorporation to thyroid could affect the…in proximity to thyroid gland, is a critical…maturation. After Chernobyl, the signs of its…
URL: http://www.sciencedirect.com/science/article/pii/B9780444522726000830
Title: 25 years after Chernobyl: lessons for Japan?,
Author: Moysich, Kirsten B / McCarthy, Philip / Hall, Per
Reference: The Lancet Oncology, 12 (5), p.416-418, May 2011
doi: 10.1016/S1470-2045(11)70095-X
Abstract: …After the Chernobyl accident, many…reported the cancer consequences…exception of thyroid cancer in young…consequences of the Chernobyl accident are studied…associating Chernobyl-related radiation and thyroid cancer in children…
URL:http://www.sciencedirect.com/science/article/pii/S147020451170095X
Title: Project Chernobyl Honored at the United Nations’ Conference
Reference: [PDF-8MB]Apr 2009
Abstract: …helping fund Project Chernobyl, an effort to diagnose thyroid cancer among the group…annual conference of Thyroid Cancer after Chernobyl, held at the United…Yorkers at risk for thyroid cancer. Project Chernobyl continues its efforts…
URL: http://www.nyee.edu/pdf/highlights-2009i-dailynews.pdf
