Author: D. Bazyka, K. Loganovsky, I. Ilyenko et al.
Reference: 8th International LOWRAD Conference «The Effects of Low Doses and Very Low Doses of Ionizing Radiation on Human Health and Biotopes», 28–30 September 2009, Rio de Janeiro, Brazil. — P. 117.
Author: Y. Iwata, K. Suzuki, T. Wakuda et al.
Reference: PLoS ONE. — 2008. — Vol. 3, № 5. — P. e2283.
Keywords: subgranular zone, immunohistochemistry, NMDA, subventicular zone
Abstract: Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia.
A total dose of 15-Gy irradiation in six fractionations during 3 weeks was exposed to the forebrain including the subventricular zone (SVZ) and subgranular zone (SGZ) with male rats in the prone position. Behavioral, immunohistochemical, and neurochemical studies were performed three months after fractionated ionizing irradiation. Three months after fractionated ionizing irradiation, the total numbers of BrdU-positive cells in both the SVZ and SGZ zones of irradiated rats were significantly lower than those of control (sham-irradiated) rats. Hyperactivity after administration of the dopaminergic agonist methamphetamine, but not the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine, was significantly enhanced in the irradiated rats although spontaneous locomotion in the irradiated rats was significantly lower than that of controls. Behavioral abnormalities including auditory sensory gating deficits, social interaction deficits, and working memory deficits were observed in the irradiated rats.
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386242/?tool=pubmed
Editors: A. Serdiuk, V. Bebeshko, D. Bazyka, S. Yamashita.
Reference: Kyiv: DIA, 2011. ― 648 pp.
Abstract: A comprehensive overview on the diverse aftermaths (health effects) of the Chernobyl accident. The subjects include acute radiation syndrome, leukemia, solid cancers, cytogenetic effects, immunology, medico-demographic issues etc.
URL:http://www-sdc.med.nagasaki-u.ac.jp/gcoe/activities/publication/20110829_e.html
Author: V. Bebeshko, D. Bazyka, K. Loganovsky et al.
Reference: Contributed papers to The International Conference “Twenty years after Chornobyl accident future outlook”, April 24–26, Kyiv, Ukraine. — Kyiv: HOLTEH, 2006. — P. 13–19.
Keywords: aging, DNA, immune function, nervous system effects
Abstract: Radiation accelerated aging might be a model of senescence in humans. Natural (normal) aging is a complex temporal process. Radiation is a phenomenon, which, by influencing cell structure and function, changes that process at the molecular and genetic level. A relation of aging and Ionizing Radiation (IR) could be demonstrated by involvement of similar mechanisms, e.g. free radical reactions, DNA repair, changes of immune function, altered lipid metabolism, nervous system effects, etc.
Concepts of immanent and interactional ambivalence (electron donor-acceptor dichotomy) of free radicals in their reactivity, and of free-radical ambivalence in biochemical processes, can be used to analyze free-radical function in normal and pathologic conditions including aging after IR exposure. Prospective epidemiological studies of atomic bomb survivors revealed IR significantly increased mortality for causes other than cancer. Results do not support claims survivors exposed to low IR doses live longer than comparable unexposed individuals. Whether exposure to low dose IR is a risk factor for accelerated aging and neurodegeneration is still unanswered and the biological mechanisms involved unknown. We propose: 1) exposure to low dose IR is a risk factor for accelerated aging and neurodegeneration; 2) heterogeneous pathogenetic factors contribute to the acceleration. International efforts to organize studies to test these hypotheses are of significance for radiation medicine and gerontology.
Author: Anderson N.E.
Reference: Curr. Opin. Neurol. — 2003. — Vol. 16, № 6. — P. 677–683.
Keywords: childhood brain tumour, Cognitive complication, endocrine dysfunction
Abstract:
PURPOSE OF REVIEW: As the treatment of childhood brain tumours has improved, long-term survival has become more common. Cognitive, physical and psychological complications of the tumour and its treatment have been recognized more frequently in long-term survivors. This review highlights new studies on the cognitive and endocrine complications in survivors. Less-common late effects of treatment are also discussed.
RECENT FINDINGS: Cognitive abnormalities and endocrine dysfunction are the most common complications in long-term survivors. Radiotherapy is the main cause of cognitive dysfunction, but intrathecal methotrexate and surgery are contributory factors. New studies have provided information on the frequency of endocrine complications and risk factors for the development of endocrine disorders. Endocrine complications are uncommon when the tumour has been treated with surgery alone. The risk of developing endocrine dysfunction is increased by radiotherapy, and some studies suggest that chemotherapy has an additional deleterious effect. Primary hypothyroidism may be caused by scattered irradiation from spinal and cranial radiotherapy. Direct involvement of the hypothalamus by the tumour, and hypothalamic damage secondary to surgery or radiotherapy, may cause obesity. Hypothalamic tumours also may be associated with hypersomnolence and other features consistent with narcolepsy. The pathogenesis of hypersomnolence in these patients has not been resolved. Long-term childhood brain-tumour survivors are 40 times more likely to develop a stroke than sibling controls. Superficial siderosis of the central nervous system can develop many years after curative treatment of a cerebellar tumour, but effective treatment for this disorder is not yet available.
SUMMARY: An attempt to understand the factors that contribute to the long-term morbidity of childhood brain tumours can lead to changes in treatment that improve the quality of life in survivors. Prevention, early recognition and treatment of these complications are attainable goals.
Author: V.G. Bebeshko, D.A. Bazyka, A.Yu. Romanenko, K.M. Loganovsky
Reference: Journal of AMS of Ukraine, 2011
Abstract: Article by Ukraine’s leading experts. Comprehends aspects of radiation safety, health protection, ecology, neuropsychiatry, immunology etc. Full text available in Ukrainian on web.
URL: http://archive.nbuv.gov.ua/portal/chem_biol/jamn/2011_2/Bebeshko.pdf
Redactor: A.M. Serdyuk, V.G. Bebeshko, D.A. Bazyka
Reference: Тернопіль: ТДМУ «Укрмедкнига» (Ternopil State Medical University), 2011
Abstract: A book redacted by some of the leading Ukrainian experts. For details please contact the Ternopil State Medical University. University’s homepage: http://www.tdmu.edu.te.ua/eng/general/index.php
Ukrainian title: Медичні наслідки Чорнобильської катастрофи 1986–2011
Author: D.A. Bazyka, N.A. Golyarnik, N.V. Belyaeva
Reference: Kiev, 2007
Abstract: There is no data on web. For detailed information on the article contact the National Scientific Center for Radiation Medicine of Ukraine. The center’s home page is: http://www.national.rcrm.net.ua/index.php/en/
Title: Clinical and laboratory criteria of the aging process acceleration among the liquidators of the Chernobyl accident
Author: Alhutova, Natalia Alexandrovna
Reference: St. Petersburg, 2005
Keywords: Clinical laboratory diagnostics, endocrine system, aging process, immune system, antioxidant system, liquidators
Abstract: Research aim; on the basis of the study of clinical-laboratory parameters of neuroendocrine, immune and antioxidant systems, to show the existence of the phenomenon of premature aging in liquidators of the Chernobyl accident.
Title: Effectiveness of children and adolescents’ rehabilitation from environmentally disadvantaged areas of the Voronezh region, under a local sanatorium terms.
Author: Aphanasenko, Lyudmila Kuzminichna
Reference: Voronezh, 2006
Keywords: rehabilitation, screening, children, adolescents, sanatorium treatment, morbidity, immune system, Voronezh Region
Abstract: Research aim: to improve the rehabilitation activities of children and adolescents who live in the Voronezh region with preferential socio-economic status under a local sanatorium terms.