タグ「neurologic manifestations」
Author: Loganovsky K.N., Yuryev K.L.
Reference: J. Neuropsychiatry Clin. Neurosci. — 2001. — Vol. 13, № 4. — P. 441–458
Keywords: EEG, cortical-limbic overactivation, organic brain damage
Abstract: Prospective conventional EEG study was carried out 3-5 and 10-13 years after the Chernobyl accident (1986) in patients who had acute radiation sickness and in emergency workers in 1986 (“liquidators”). Control groups comprised healthy volunteers; veterans of the Afghanistan war with posttraumatic stress disorder; veterans with mild traumatic brain injury; and patients with dyscirculatory encephalopathy. In 3-5 years after irradiation, there were irritated EEG changes with paroxysmal activity shifted to the left frontotemporal region (cortical-limbic overactivation) that were transformed 10-13 years after irradiation toward a low-voltage EEG pattern with excess of fast (beta) and slow (delta) activity together with depression of alpha and theta activity (organic brain damage with inhibition of the cortical-limbic system). Quantitative EEG is likely to be very informative for investigation of dose-effect relationships.
URL: http://neuro.psychiatryonline.org/article.aspx?articleid=101516
Author: Loganovsky K.N., Loganovskaja T.K.
Reference: Schizophr. Bull. — 2000. — Vol. 26, № 4. — P. 751–773.
Keywords: schizophrenia, psychophysiological examination, left frontotemporal limbic and schizophreniform syndromes
Abstract: We studied schizophrenia spectrum disorders in Chernobyl accident survivors by analyzing Chernobyl exclusion zone (EZ) archives (1986-1997) and by conducting a psychophysiological examination of 100 patients with acute radiation sickness (ARS) and 100 workers of the Chernobyl EZ who had worked as “liquidators-volunteers” for 5 or more years since 1986-1987. Beginning in 1990, there has been a significant increase in the incidence of schizophrenia in EZ personnel in comparison to the general population (5.4 per 10,000 in the EZ versus 1.1 per 10,000 in the Ukraine in 1990). Those irradiated by moderate to high doses (more than 0.30 Sv or 30 rem), including ARS patients, had significantly more left frontotemporal limbic and schizophreniform syndromes. We hypothesized that ionizing radiation may be an environmental trigger that can actualize a predisposition to schizophrenia or indeed cause schizophrenia-like disorders. The development of schizophrenia spectrum disorders in overirradiated Chernobyl survivors may be due to radiation-induced left frontotemporal limbic dysfunction, which may be the neurophysiological basis of schizophrenia-like symptoms. Persons exposed to 0.30 Sv or more are at higher risk of schizophrenia spectrum disorders. An integration of international efforts to discuss and organize collaborative studies in this field is of great importance for both clinical medicine and neuroscience. (full text available on web)
URL: http://schizophreniabulletin.oxfordjournals.org/content/26/4/751.long
Author: Loganovsky K.N.
Reference: Journal of Chronic Fatigue Syndrome. — 2000. — Vol. 7, № 3. — P. 3–16.
Keywords: CFS, MMPI, qEEG, SSEP
Abstract: The aim of this study was to determine whether the Chronic Fatigue Syndrome (CFS) definition could be applicable to the assessment of the medical aftermath of radioecological disasters and to investigate a possible psychophysiological basis of fatigue in Chernobyl accident survivors.
One hundred randomly selected clean-up workers of the Chernobyl accident who presented with complaints of fatigue were examined neuropsychiatrically using MMPI profiles, Quantitative Electroencephalography (QEEG) and Somatosensory evoked potentials (SSEP). Twenty-six percent of them met the CFS diagnostic criteria. Their absorbed radiation doses were less than 0.3 Sv, an exposure level that is not expected to produce a clear deterministic radiation effect. Clinical symptomatology included persistent fatigue, odd skin sensations, bizarre feelings in bones, muscles and joints, irritability, headache, vertigo, pain in the chest area, emotional lability, irritability, lack of concentration and memory, cognitive deterioration,
depression signs and sleep disorders.
UTL: http://www.ncf-net.org/radiation/Vegetative_dystonia_CFS.pdf
Author: Loganovsky K.N.
Reference: Florence, Italy, January 17-19, 2013. — pp. 77–85
Author: Loganovsky K.N.
Reference: Clinical Neuropsychiatry — 2012. — Vol. 9, № 5. — P. 203-204
Author: Loganovsky K.
Reference: Data Science Journal. — 2009. — Vol. 8. — BR13–BR35
Keywords: Ionizing radiation, Low doses, Chernobyl accident, Brain, Radiosensitivity, Radiocerebral effects, exposure in utero
Abstract: The aim of this paper is to analyze the current evidence on radiocerebral effects following exposure to 20 mSv on the fetus and >300 mSv on the thyroid in utero; at 16–25 weeks, abnormalities were >10 mSv and >200 mSv, respectively. In adults, radiationassociated cerebrovascular effects were obtained at >0.15-0.25 Sv. Dose-related neuropsychiatric, neurophysiological, neuropsychological, and neuroimaging abnormalities following exposure to >0.3 Sv and neurophysiological and neuroimaging radiation markers at doses >1 Sv were revealed. Studies on radiation neuropsychiatric effects should be undertaken.
URL: https://www.jstage.jst.go.jp/article/dsj/8/0/8_BR-04/_pdf
Author: Kolominsky Y., Igumnov S., Drozdovitch V J.
Reference: Child Psychol. Psychiatry. — 1999. — Vol. 40, № 2. — P. 299–305
Keywords: physiology, psychiatry, speech-language disorder, IQ
Abstract: This study examined psychological development in 138 children at the age of 6-7 and 10-11 years, who had suffered prenatal radiation exposure at the time of the Chernobyl accident in 1986. These children were compared to a control group of 122 children of the same age from noncontaminated areas of Belarus. The examination included neurological and psychiatric examination, intellectual assessment, and clinical psychological investigation of parents as well as the estimation of thyroid exposure in utero. The exposed group manifested a relative increase in psychological impairment compared with the control group, with increased prevalence in cases of specific developmental speech-language disorders (18.1% vs. 8.2% at 6-7 years; 10.1% vs. 3.3% at 10-11 years) and emotional disorders (20.3% vs. 7.4% at 6-7 years; 18.1 vs. 7.4% at 10-11 years). The mean IQ of the exposed group was lower than that of the control group, and there were more cases of borderline IQ (IQ = 70-79) (15.9% vs. 5.7% at 6-7 years; and 10.1% vs. 3.3% at 10-11 years). The mean value of thyroid doses from 131I 0.4 Gy was estimated for children exposed in utero. No correlation was found between individual thyroid doses and IQ at age 6-7 years or 10-11 years. We notice a positive moderate correlation between IQ of children and the educational level of their parents. There was a moderate correlation between high personal anxiety in parents and emotional disorders in children. We conclude that a significant role in the genesis of borderline intellectual functioning, specific developmental disorders of speech, language and scholastic skills, as well as emotional disorders in the exposed group of children was played by unfavourable social-psychological and social-cultural factors such as a low educational level of parents, the break of microsocial contacts, and adaptational difficulties, which appear following the evacuation and relocation from the contaminated areas.
URL: http://www.ncbi.nlm.nih.gov/pubmed/10188713
Reference: ― New York: Academic Press, 1965. ― 365 p.
Keywords: neurology
Abstract: Prepared under the direction of the American Institute of Biological Sciences for the Division of Technical Information, United States Atomic Energy Commission
URL: http://trove.nla.gov.au/work/8568261?versionId=9900454
Author: Y. Iwata, K. Suzuki, T. Wakuda et al.
Reference: PLoS ONE. — 2008. — Vol. 3, № 5. — P. e2283.
Keywords: subgranular zone, immunohistochemistry, NMDA, subventicular zone
Abstract: Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia.
A total dose of 15-Gy irradiation in six fractionations during 3 weeks was exposed to the forebrain including the subventricular zone (SVZ) and subgranular zone (SGZ) with male rats in the prone position. Behavioral, immunohistochemical, and neurochemical studies were performed three months after fractionated ionizing irradiation. Three months after fractionated ionizing irradiation, the total numbers of BrdU-positive cells in both the SVZ and SGZ zones of irradiated rats were significantly lower than those of control (sham-irradiated) rats. Hyperactivity after administration of the dopaminergic agonist methamphetamine, but not the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine, was significantly enhanced in the irradiated rats although spontaneous locomotion in the irradiated rats was significantly lower than that of controls. Behavioral abnormalities including auditory sensory gating deficits, social interaction deficits, and working memory deficits were observed in the irradiated rats.
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386242/?tool=pubmed
Author: S. Bazyltchik, V.M. Drozd, Chr. Reiners, Yu. Gavrilin
Reference: International Journal of Radiation Medicine. — 2001. — Special Issue 3, № 1–2. — P. 15.
