カテゴリー「thyroid cancer」
Title: Chapter 8 Mechanisms of radiation-induced carcinogenesis: The thyroid model
Author: Nikiforov, Yuri E. / Fagin, James A.
Reference: Advances in Molecular and Cellular Endocrinology, 2, p.169-196, Jan 1998
doi: 10.1016/S1569-2566(98)80016-1
Keywords: biological effects of radiation , papillary carcinoma, children
Abstract: Based on present information on the biological effects of radiation, the ultimate nature of the genetic events giving rise to the papillary carcinomas in the exposed children may have resulted either directly from DNA damage to oncogenic sequences (that is, ret/PTC), or may be due to downstream events taking place after the genome of the affected cell has been destabilized by as yet unexplained mechanisms. It is now clear that radiationinduced papillary carcinomas of Chernobyl have certain “signature” genetic features—namely a high prevalence of a particular form of ret/PTC rearrangement. This provides a definable end-point for future studies of radiation-induced DNA damage in thyroid cells, and may allow for the testing of more targeted hypothesis as to the natural history of these tumors. The exposure to the thyroid gland resulted from internal irradiation from absorbed shortlived radioiodines and, to a lesser extent, penetrating gamma radiation. Appearance of thyroid carcinomas was noted 10 years after the exposure, with seven papillary, one follicular, and seven occult thyroid cancers diagnosed among the 250 exposed individuals during 34 years of careful monitoring.
URL: http://www.sciencedirect.com/science/article/pii/S1569256698800161
Title: Oncogenic rearrangements of the ret proto-oncogene in thyroid tumors induced after exposure to ionizing radiation
Author: Bounacer, A. / Wicker, R. / Schlumberger, M. / Sarasin, A. / Suárez, H.G.
Reference: Biochimie, 79 (9-10), p.619-623, Oct 1997
doi: 10.1016/S0300-9084(97)82012-3
Keywords: radiation-associated thyroid tumors; ret proto-oncogene; activating rearrangements; RET/PTC oncogene
Abstract: A high frequency (≃ 60%) of ret rearrangements in Chernobyl papillary thyroid c, reinomas (PTC) has been reported recently. The data suggested that the radiation exposure may be a direct inducer of activating rearrangements in the ret gene. In our study, we have analyzed for the presence of RET/PTC oncogenes using the RT-PCR, XL-PCR. Southern blot and direct sequencing techniques, 39 human thyroid tumors from patients who had received external radiation for benign or malignant conditions. As controls, we studied 39 ‘spontaneous’ tumors. Our results indicate that: 1) the overall frequency of ret rearrangements was 84% in papillary carcinomas () and 45% () in follicular adenomas; 2) in contrast with the results obtained in the Chernobyl tumors, the most frequently observed chimeric gene was RET/PTC1; and 3) all the tumors were negative for RET/PTC2. In the ‘spontaneous’ tumors, only the papillary carcinomas presented a ret rearrangement (15%; ). Our data confirm the crucial role played by the ret proto-oncogene activating rearrangements in the development of radiation-associated thyroid tumors, and show, for the first time, the presence of RET/PTC genes in follicular adenomas appeared after external irradiation.
URL: http://www.sciencedirect.com/science/article/pii/S0300908497820123
Title: David V Becker
Author: Williams, Ruth
Reference: The Lancet, 375 (9723), p.1342, Apr 2010
doi: 10.1016/S0140-6736(10)60566-1
Keywords: Radiologist, thyroid endocrinologist
Abstract: Radiologist, thyroid endocrinologist, humanitarian. Born on May 24, 1923, in New York, USA, he died of heart disease on Jan 31, 2010, in New York aged 86 years.
Hyperthyroidism and thyroid cancer are nowadays routinely treated by the administration of radioactive iodine. In the 1950s, however, the field of nuclear medicine was in its infancy and David Becker and his colleagues were pioneers. Becker was among the first to use radioiodine for imaging the thyroid, and for diagnosing and treating thyroid diseases. He established radioiodine as a clinical tool, but also studied its adverse effects after high-level exposure. This expertise was called upon in the wake of the Chernobyl power plant explosion of 1986.
URL:http://www.sciencedirect.com/science/article/pii/S0140673610605661
Title: Rearrangements of NTRK1 gene in papillary thyroid carcinoma
Author: Greco, A. / Miranda, C. / Pierotti, M.A.
Reference: Molecular and Cellular Endocrinology, 321 (1), p.44-49, May 2010
doi: 10.1016/j.mce.2009.10.009
Keywords: NTRK1; Gene rearrangement; Papillary thyroid tumor
Abstract: …starting from papillary thyroid tumor DNA. Transforming…isolated from papillary thyroid tumors are reported in Table…radioiodine released from the Chernobyl reactor a high rate of…event in the process of thyroid carcinogenesis. Transgenic…penetrance of thyroid cancer and shortens the latency…
URL: http://www.sciencedirect.com/science/article/pii/S0303720709005565
Title: The Chernobyl Tissue Bank A Repository for Biomaterial and Data Used in Integrative and Systems Biology Modeling the Human Response to Radiation
Author: Geraldine Thomas, Kristian Unger, Marko Krznaric, Angela Galpine, Jackie Bethel, Christopher Tomlinson, Mark Woodbridge, Sarah Butcher
Reference: Genes 2012, 3, 278-290; [PDF-203K]May 2012
doi:10.3390/genes3020278
Keywords: Chernobyl; Tissue Bank; systems biology
Abstract: The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence. In response to the scientific interest in studying the molecular biology of thyroid cancer post Chernobyl, the Chernobyl Tissue Bank (CTB: www.chernobyltissuebank.com) was established in 1998. Thus far it is has collected biological samples from 3,861 individuals, and provided 27 research projects with 11,254 samples. The CTB was designed from its outset as a resource to promote the integration of research and clinical data to facilitate a systems biology approach to radiation related thyroid cancer. The project has therefore developed as a multidisciplinary collaboration between clinicians, dosimetrists, molecular biologists and bioinformaticians and serves as a paradigm for tissue banking in the omics era.
URL: http://www.mdpi.com/2073-4425/3/2/278/pdf
Title: Chapter 30 – Oncogenes in Thyroid Tumors
Author: Goretzki, Peter E. / Gorelev, Victor / Simon, Dietmar / Roeher, Hans-Dietrich
Reference: Textbook of Endocrine Surgery, Jan 2005
ISBN:9780721601397
Abstract: …i.e., thyrotropin or thyroid-stimulating hormone [TSH…e.g., prevalence of thyroid cancer in Russia before and after the Chernobyl catastrophe), toxicology…roles of oncogenes in human thyroid tumors. Oncogenes Connected…
URL:http://www.sciencedirect.com/science/article/pii/B978072160139750034X
Title: Chernobyl Studies Project. Working Group 7.0, environmental transport and health effects. Progress report, February 1994
Author: Hendrickson, S.M.
Reference: DOE Scientific and Technical Information Apr 1994
doi: 10.2172/10166899
Keywords: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 61 RADIATION PROTECTION AND DOSIMETRY; 54 ENVIRONMENTAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; CHILDREN; BIOLOGICAL RADIATION EFFECTS; ENVIRONMENTAL EXPOSURE PATHWAY; CHERNOBYLSK-4 REACTOR; REACTOR ACCIDENTS; FALLOUT; DOSE RATES; RADIONUCLIDE MIGRATION; DOSIMETRY; THYROID; PROGRESS REPORT
Abstract: …occurring prior to the Chernobyl accident), ( 2) Dr…associated with the Chernobyl accident, and ( 3…a direct part of the Chernobyl Project. However…study on childhood-thyroid cancer. Also, we need…
URL: http://www.osti.gov/bridge/product.biblio.jsp?query_id=2&page=0&osti_id=10166899
Title: The intellectual development, mental and behavioural disorders in children from Belarus exposed in utero following the Chernobyl accident
Author: Igumnov, S / Drozdovitch, V
Reference: European Psychiatry, 15 (4), p.244-253, Jun 2000
doi: 10.1016/S0924-9338(00)00237-6
Keywords: education; emotional disorder; exposure; prenatal; social factors; specific learning ; thyroid dose
Abstract: The study examined psychological development in 250 children at the age of 6–7 and 10–12 years who had been exposed in the prenatal period at the time of the Chernobyl accident in 1986. These children were compared to a control group of 250 children of the same age from non- and slightly contaminated areas of Belarus. The examination included psychiatric examination and intellectual assessment as well as the estimation of thyroid exposure in utero. The mean value of thyroid doses from 131I 0.39 Gy was estimated for the prenatal exposed children….
URL: http://www.sciencedirect.com/science/article/pii/S0924933800002376
Title: Role of Epac and protein kinase A in thyrotropin-induced gene expression in primary thyrocytes
Author: van Staveren, Wilma C.G. / Beeckman, Sandrine / Tomás, Gil / Dom, Geneviève / Hébrant, Aline / Delys, Laurent / Vliem, Marjolein J. / (…) / Maenhaut, Carine
Reference: Experimental Cell Research, 318 (5), p.444-452, Mar 2012
doi: 10.1016/j.yexcr.2011.12.022
Keywords: Epac; Rap; RapGAP; Thyroid; Cancer; Microarrays
Abstract: …non-treated cells. Malignant thyroid tumors and microarrays The…investigated in a panel of malignant thyroid tumors. This group of cancers…twenty PTC and twenty adjacent thyroid tissues to the latter that…PTC, n = 10) and from the Chernobyl Tissue Bank (CTB) (post-Chernobyl…
URL: http://www.sciencedirect.com/science/article/pii/S0014482711005039
Title: The Lesson learned from the Chernobyl Accident and the Data from Atomic Bomb Survivors ―For Understanding the Fukushima Daiichi Accident and the Robustness of the Human Body to Ionizing Radiation ―
Author: Ken-ichiroSUGIYAMA
Reference: [PDF-2MB]April 12, 2011
Abstract: …prevailing wind. The Chernobyl reactor was completely…330km Gomel ~130km Chernobyl The Distribution of Cesium…of Radiation from the Chernobyl Disaster 1. When the…about 1,800 cases of thyroid cancer in children according…
URL: http://ocw.hokudai.ac.jp/OpenLecture/Symposium/2011/FukushimaNuclearPowerPlant/page/materials/FukushimaNuclearPowerPlant-2011-Slide-02.pdf
