Title: Surgical treatment of thyroid diseases in elderly patients
Author: Raffaelli, Marco / Bellantone, Rocco / Princi, Pietro / De Crea, Carmela / Rossi, Esther D. / Fadda, Guido / Lombardi, Celestino P.
Reference: The American Journal of Surgery, 200 (4), p.467-472, Oct 2010
doi: 10.1016/j.amjsurg.2009.12.020
Keywords: Elderly patients; Thyroid surgery; Thyroidectomy; Geriatric surgery; Thyroid cancer; Toxic goiter
Abstract: …surgery and treat the thyroid disease conservatively…therapy. The incidence of thyroid cancer has increased in recent…of incidence after the Chernobyl accident. 3,4 It is…factor in differentiated thyroid carcinoma. 5 Furthermore…
URL: http://www.sciencedirect.com/science/article/pii/S000296101000173X
Title: De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma
Author: Rath, Geraldine / Schneider, Christophe / Langlois, Benoit / Sartelet, Hervé / Morjani, Hamid / Btaouri, Hassan E.L. / Dedieu, Stephane / Martiny, Laurent
Reference: The International Journal of Biochemistry & Cell Biology, 41 (5), p.1165-1172, May 2009
doi: 10.1016/j.biocel.2008.10.021
Keywords: Ceramide; Apoptosis; Thyroid; Cancer; Doxorubicin; Camptothecin
Abstract: …treatment. Follicular thyroid carcinomas were cultured for…control). 1 Introduction Thyroid malignant diseases represent…1995 ). After the Chernobyl tragedy in April 1986, the incidence rate of thyroid cancers rose more than…well-differentiated form of thyroid cancer, accounts for up to…
URL: http://www.sciencedirect.com/science/article/pii/S1357272508004433
Title: Radioactivity in persons exposed to fallout from the Chernobyl reactor accident
Author: Schlenker, R.A. / Oltman, B.G. / Lucas, H.F.
Reference: DOE Scientific and Technical Information Jan 1987
Abstract: Measurements of fallout radioactivity were made in the thyroid region, abdomen, whole body, or urine of 96 persons who were in eastern Europe at the time of the Chernobyl reactor accident or who went there shortly afterward. The most frequently encountered radionuclides were /sup 131/I, sup 134,137/Cs, and /sup 103/Ru//sup 103/Rh. The median /sup 131/I activity in the thyroids of 42 subjects in whom radioiodine was detected and who were in Europe when the accident began was projected as 42 nCi the day the accident began….
URL: http://www.osti.gov/bridge/product.biblio.jsp?query_id=2&page=0&osti_id=5835048
Title: Internally deposited fallout from the Chernobyl reactor accident
Author: Schlenker, R.A. / Oltman, B.G. / Lucas, H.F.
Reference: DOE Scientific and Technical Information Jan 1987
Abstract: Measurements of fallout radioactivity were made in the thyroid region, abdomen, whole body, or urine of 96 persons who were in eastern Europe at the time of the Chernobyl reactor accident or who went there shortly afterward. The most frequently encountered radionuclides were /sup 131/I, /sup 134,137/Cs, and /sup 103/Ru//sup 103/Rh. The median /sup 131/I activity in the thyroids of 42 subjects in whom radioiodine was detected and who were in Europe when the accident began was projected as 42 nCi the day the accident began….
URL: http://www.osti.gov/bridge/product.biblio.jsp?query_id=2&page=0&osti_id=5467237
Title: Polymorphisms in the p53 gene in thyroid tumours and blood samples of children from areas in Belarus
Author: Hillebrandt, S / Streffer, C / Demidchik, E.P / Biko, J / Reiners, Chr,
Reference: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 381 (2), p.201-207, Nov 1997
doi: 10.1016/S0027-5107(97)00169-3
Abstract: We present changes in the p53 gene in a group of 70 thyroid tumours and 40 blood samples obtained from children from Belarus. Three thyroid tumours show a polymorphism in exon 6 (codon 213) and 5 tumours show a polymorphism in intron 6, 37 bp upstream to the 5′-end of exon 7. Only one patient has a mutation in exon 7 (codon 258) resulting in an amino acid substitution in the protein p53. …One polymorphism in intron 6 was also found in the group of 30 healthy children from Belarus. The fact that the differences in the sequence in p53 found in the tumours was also seen in the blood of these patients demonstrates that they are polymorphisms not induced by radiation exposure. It is difficult to conclude, if the polymorphisms found by us could be associated with the predisposition to radiation-induced cancer.
URL: http://www.sciencedirect.com/science/article/pii/S0027510797001693
Title: Health risks associated with environmental radiation exposures
Author: Scott Davis
Reference: Journal of Radiological Protection, 32 (1), p.N21-N25, Mar 2012
doi: 10.1088/0952-4746/32/1/N21
Abstract: An accident like Chernobyl or a natural disaster like that at Fukushima provides a unique opportunity to learn more about the health risks from environmental radiation exposures. However, establishing the infrastructure and expertise required to design and conduct all aspects of a complex field study presents formidable challenges. This paper summarises the principal findings from the main studies of environmental radiation exposure that have been successfully undertaken. Although such studies are often exceedingly difficult to conduct, and may be limited by an ecologic design, they can be informative in assessing risk. Any new environmental study that is initiated should focus on special circumstances; additional ecological studies are not recommended.
URL: http://iopscience.iop.org/0952-4746/32/1/N21/
Title: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
Author: Nikiforova, Marina N / Ciampi, Raffaele / Salvatore, Giuliana / Santoro, Massimo / Gandhi, Manoj / Knauf, Jeffrey A / Thomas, Gerry A / (…) / Nikiforov, Yuri E
Reference: Cancer Letters, 209 (1), p.1-6, Jun 2004
doi: 10.1016/j.canlet.2003.12.004
Keywords: Thyroid cancer; BRAF mutation; RET/PTC Rearrangement; Radiation exposure
Abstract: Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
URL:http://www.sciencedirect.com/science/article/pii/S0304383503008334
Title: Irradiation and second cancers. The thyroid as a case in point
Author: Schlumberger, Martin / Cailleux, Anne-Françoise / Suarez, Horacio G / de Vathaire, Florent
Reference: Comptes Rendus de l’Académie des Sciences – Series III – Sciences de la Vie, 322 (2-3), p.205-213, Feb 1999
doi: 10.1016/S0764-4469(99)80045-6
Keywords: irradiation; thyroid tumours; Chernobyl; RET rearrangements
Abstract: …Radioiodine 131 (1311) used for medical purposes has almost no tumourigenic effect on the adult thyroid gland. The consequences of the Chernobyl accident have clearly shown that the risk of thyroid cancer after exposure to 1311 in childhood is important, and that such exposure should be prevented by potassium iodine prophylaxis. RET/PTC rearrangements are found in 60–80 % of papillary carcinomas and in 45 % of adenomas occurring after radiation exposure. They are found in 5–15 % of papillary carcinoma and in no follicular adenomas that occurred in the absence of radiation exposure.
URL:http://www.sciencedirect.com/science/article/pii/S0764446999800456
Title: Radiation Exposures Due to the Chernobyl Accident
Author: Balonov, M. / Bouville, A.
Reference: Encyclopedia of Environmental Health, Jan 2011
ISBN:9780444522726
Keywords: Background radiation; Cesium-137; Chernobyl accident; Effective dose; Environmental consequences; Environmental transfer; Exposure pathways; External dose; Health consequences; Internal dose; Iodine-131; Radionuclide; Thyroid dose
Abstract: …exposure such as the Chernobyl accident, living…Pathways Related to the Chernobyl Accident…environment, such as the Chernobyl accident, is required…accident was an elevated thyroid cancer incidence in children…
URL:http://www.sciencedirect.com/science/article/pii/B9780444522726000866
Title: The World Health Organization and Sasakawa Memorial Health Foundation joint project: medical relief for children affected by the Chernobyl accident through the development and implementation of health telematics
Author: Repacholi, Michael N. / Takamura, Noboru / Souchkevitch, Guennadi N.
Reference: International Congress Series, 1234, p.135-140, May 2002
doi: 10.1016/S0531-5131(01)00604-5
Keywords: Chernobyl; Telemedicine; Health telematics; Thyroid cancer
Abstract: The World Health Organization (WHO) and Sasakawa Memorial Health Foundation (SMFH), in cooperation with the Ministry of Health of the Republic of Belarus (the Ministry), have established and promoted a project entitled “Medical Relief for Children Affected by the Chernobyl Accident through the Development and Implementation of Health Telematics” to improve early diagnosis of thyroid diseases and follow-up of patients who have developed thyroid cancer due to exposure to radioactive fallout. The article reviews the development and current status of the project.
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006045
