タグ「oncogenes」
Title: Can different thyroid tumor types be distinguished by polymerase chain reaction-based K- ras mutation detection?
Author: Apple, Sophia K. / Alzona, Maria C. / Jahromi, Soraya A. / Grody, Wayne W.
Reference: Molecular Diagnosis, 3 (3), p.143-148, Sep 1998
doi: 10.1016/S1084-8592(98)80032-5
Keywords: follicular adenoma; follicular carcinoma; papillary carcinoma; oncogenes
Abstract: Thyroid tumors have mutations of the ras oncogenes, although the prognostic and diagnostic significance of this remains unclear. Usually, thyroid follicular adenoma, follicular carcinoma, and papillary carcinoma are easy to differentiate histologically. Occasionally, follicular carcinoma may be difficult to separate from the follicular variant of papillary carcinoma, and a molecular test to help differentiate the two would be critical, as their behavior and clinical management differ. In earlier reports, K-ras mutations have been suggested as such a marker.
…normal and proliferative thyroid tissues. Am J Pathol…carcinomas arising from thyroid epithe- lial follicular cells. Gene Chromosomes Cancer 1996;16:1-14 22…benign and malignant thyroid tumors from children…to radiation after the Chernobyl nuclear accident. Oncogene…
URL: http://www.sciencedirect.com/science/article/pii/S1084859298800325
Title: Chapter 30 – Oncogenes in Thyroid Tumors
Author: Goretzki, Peter E. / Gorelev, Victor / Simon, Dietmar / Roeher, Hans-Dietrich
Reference: Textbook of Endocrine Surgery, Jan 2005
ISBN:9780721601397
Abstract: …i.e., thyrotropin or thyroid-stimulating hormone [TSH…e.g., prevalence of thyroid cancer in Russia before and after the Chernobyl catastrophe), toxicology…roles of oncogenes in human thyroid tumors. Oncogenes Connected…
URL:http://www.sciencedirect.com/science/article/pii/B978072160139750034X
Title: Chapter 30 – Oncogenes in Thyroid Tumors
Author: Goretzki, Peter E. / Gorelev, Victor / Simon, Dietmar / Roeher, Hans-Dietrich
Reference: Textbook of Endocrine Surgery, Jan 2005
ISBN:9780721601397
Abstract: …i.e., thyrotropin or thyroid-stimulating hormone [TSH…e.g., prevalence of thyroid cancer in Russia before and after the Chernobyl catastrophe), toxicology…roles of oncogenes in human thyroid tumors. Oncogenes Connected…
URL:http://www.sciencedirect.com/science/article/pii/B978072160139750034X
Title: Oncogene profile of papillary thyroid carcinoma
Author: Sugg, Sonia L. / Ezzat, Shereen / Zheng, Lei / Freeman, Jeremy L. / Rosen, Irving B. / Asa, Sylvia L.
Reference: Surgery, 125 (1), p.46-52, Jan 1999
doi: 10.1016/S0039-6060(99)70287-4
Abstract: …suppressor genes in thyroid cancer is a subject of intense…a group of papillary thyroid cancers. Mutations…radiation fallout from the Chernobyl nuclear accident…oncogene rearrangement in thyroid cancer and other potentially…
URL: http://www.sciencedirect.com/science/article/pii/S0039606099702874
Title: Chapter 31 – Thyroid Oncogenesis
Author: Kebebew, Electron
Reference: Textbook of Endocrine Surgery, Jan 2005
ISBN:9780721601397
Abstract: …sporadic papillary thyroid cancer is variable, ranging from…rearrangement genes m papillary thyroid cancer may be due to geographic…P'” For example, in thyroid neoplasms associated with the Chernobyl accident, 55% to 85% of…
URL: http://www.sciencedirect.com/science/article/pii/B9780721601397500351
Title: Chromosomal aberrations in thyroid follicular-cell neoplasia: in the search of novel oncogenes and tumour suppressor genes
Author: Zitzelsberger, Horst / Thomas, Gerry / Unger, Kristian
Reference: Molecular and Cellular Endocrinology, 321 (1), p.57-66, May 2010
doi: 10.1016/j.mce.2009.11.014
Keywords: Follicular-cell neoplasia; Tumour suppressor gene; Oncogene; FISH; Chromosome; Rearrangement; Copy number alteration; Next-generation sequencing;Array CGH; Array painting
Abstract: …than just thyroid cancer, the reader…from the Chernobyl accident…papillary thyroid cancer. A recent…in post-Chernobyl and sporadic…in post-Chernobyl cases (aged…childhood thyroid papillary…papillary cancer are not necessarily…
URL: http://www.sciencedirect.com/science/article/pii/S0303720709005796
Title: Molecular pathogenesis of thyroid cancer
Author: Segev, Dorry L. / Umbricht, Christopher / Zeiger, Martha A.
Reference: Surgical Oncology, 12 (2), p.69-90, Aug 2003
doi: 10.1016/S0960-7404(03)00037-9
Keywords: Thyroid cancer; Oncogenes; Tumor suppressor genes; Growth hormones; Telomerase
Abstract: …gsp mutations in human thyroid tumors Tumor type gsp…ras mutations in human thyroid tumors Tumor type ras…PTC3 RET/PTC5 post-Chernobyl patients; RFG-5…rearrangements in human thyroid tumors Tumor type RET…Introduction Thyroid cancer is the most common endocrine…
URL: http://www.sciencedirect.com/science/article/pii/S0960740403000379
Title: Molecular pathology of thyroid cancer: diagnostic and clinical implications
Author: Fagin, James A. / Mitsiades, Nicholas
Reference: Best Practice & Research Clinical Endocrinology & Metabolism, 22 (6), p.955-969, Dec 2008
doi: 10.1016/j.beem.2008.09.017
Keywords: thyroid cancer; pathogenesis; oncogene; RET; BRAF; RAS; molecular diagnostics; PTEN; PI3 kinase
Abstract: …receptor (RET/PTC) in thyroid cells that are constitutively…a very early event in thyroid cancer development. Thus…11 or RET/PTC3 12 in thyroid cells. In addition…characteristics. In post-Chernobyl pediatric cancers RET…
URL: http://www.sciencedirect.com/science/article/pii/S1521690X08001127
Title: RET oncogene amplification in thyroid cancer: Correlations with radiation-associated, high-grade malignancy, and genomic instability
Author: Nakashima, Masahiro / Takamura, Noboru / Namba, Hiroyuki / Saenko, Vladimir A. / Suzuki, Keiji / Meirmanov, Serik / Hayashi, Tomayoshi / Sekine, Ichiro
Reference: International Congress Series, 1299, p.251-255, Feb 2007
doi: 10.1016/j.ics.2006.09.002
Keywords: Thyroid cancer; RET oncogene; Genomic instability; 53BP1; Radiation; Interphase FISH
Abstract: RET oncogene rearrangement is a well-known molecular alteration observed in papillary thyroid cancer (PTC). RET rearrangement is the commonest oncogenic alterations in Chernobyl-related PTC; nearly all to RET/PTC1 or RET/PTC3, resulting from paracentric inversion of chromosome 10. Other less common variants, usually forming as a result of interchromosomal translocation, occur in an extremely limited number of cases….
URL:http://www.sciencedirect.com/science/article/pii/S0531513106006182
Title: : Radioiodine-induced thyroid cancer: Studies in the aftermath of the accident at Chernobyl
Author Robbins, Jacob / Schneider, Arthur B
Reference: Trends in Endocrinology & Metabolism, 9 (3), p.87-94, Apr 1998
doi: 10.1016/S1043-2760(98)00024-1
Keywords: radiation; thyroid cancer; thyroid oncogenes; radioiodine; Chernobyl cancer
Abstract: While a great deal is known about the relationship between external radiation exposure and thyroid cancer, much less is known about the oncogenic effects of internal radiation exposure from isotopes of iodine. The accident at the Chernobyl nuclear power plant released massive quantities of radioiodine isotopes into the atmosphere. The large number of ensuing thyroid cancers in exposed children leaves little doubt that these malignancies have occurred as a result of the accident. However, carefully planned epidemiological studies are needed to confirm that these are due predominantly to I-131 exposure, to determine the dose-response relationship, to monitor for continuing effects and to evaluate other contributing factors. Preliminary evidence indicates that there is a distinct pattern of somatic genetic changes in the thyroid cancers from the Chernobyl area.
URL: http://www.sciencedirect.com/science/article/pii/S1043276098000241
